Evidence map›Paper›PMID 24439485›Full record

ArticleNeurobiology of aging2014

Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults.

Yi-Fang Chuang, Dana Eldreth, Kirk I Erickson, Vijay Varma, Gregory Harris, Linda P Fried, George W Rebok, Elizabeth K Tanner, Michelle C Carlson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Diabetes and Cognitive Decline in Older Adults: The Ginkgo Evaluation of Memory Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Trial
  5. Trial
  6. Impact of the Baltimore Experience Corps Trial on cortical and hippocampal volumes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015
    Trial
  7. Trial
  8. Article
  9. Article
  10. Observational
  11. The Impact of the BAILAMOS™ Dance Program on Brain Functional Connectivity and Cognition in Older Latino Adults: A Pilot Study.Journal of cognitive enhancement : towards the integration of theory and practice · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Effects of a mental stress challenge on brain function in coronary artery disease patients with and without depression.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yi-Fang ChuangDepartment of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Dana EldrethDepartment of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Kirk I EricksonDepartment of Psychology, University of Pittsburgh, PA, USA.
Vijay VarmaDepartment of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA; Johns Hopkins Center on Aging and Health, Baltimore, MD, USA.
Gregory HarrisJohns Hopkins Center on Aging and Health, Baltimore, MD, USA.
Linda P FriedColumbia University Mailman School of Public Health, New York, NY, USA.
George W RebokDepartment of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA; Johns Hopkins Center on Aging and Health, Baltimore, MD, USA.
Elizabeth K TannerJohns Hopkins Center on Aging and Health, Baltimore, MD, USA; Schools of Nursing, Johns Hopkins University, Baltimore, MD, USA.
Michelle C CarlsonDepartment of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA; Johns Hopkins Center on Aging and Health, Baltimore, MD, USA. Electronic address: mcarlson@jhsph.edu.
Johns Hopkins University · USColumbia University · USUniversity of Pittsburgh · US

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
SOCIAL AND PSYCHOLOGICAL BENEFITS OF EXPERIENCE CORPS PARTICIPATIONP01AG027735 · NIA · JOHNS HOPKINS UNIVERSITY · PI REBOK, GEORGE W. · 2006 to 2013
$10.9M
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3M
NIA NIH HHS P01 AG027735NIA NIH HHS P01 AG027735-03NIA NIH HHS P30 AG021334NIA NIH HHS T32 AG027668
6 · The paper itself

Abstract

Cardiovascular (CV) risk factors, such as hypertension, diabetes, and hyperlipidemia are associated with cognitive impairment and risk of dementia in older adults. However, the mechanisms linking them are not clear. This study aims to investigate the association between aggregate CV risk, assessed by the Framingham general cardiovascular risk profile, and functional brain activation in a group of community-dwelling older adults. Sixty participants (mean age: 64.6 years) from the Brain Health Study, a nested study of the Baltimore Experience Corps Trial, underwent functional magnetic resonance imaging using the Flanker task. We found that participants with higher CV risk had greater task-related activation in the left inferior parietal region, and this increased activation was associated with poorer task performance. Our results provide insights into the neural systems underlying the relationship between CV risk and executive function. Increased activation of the inferior parietal region may offer a pathway through which CV risk increases risk for cognitive impairment.

Indexed as

AgedBrainCardiovascular DiseasesCognition DisordersDementiaExecutive FunctionFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsBrain functionCardiovascular riskExecutive functionfMRIFramingham risk scoreOlder adults

Identifiers

PMID24439485
PMCPMC4282177
OpenAlexW2087804317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.