ReviewTrends in genetics : TIG2014
Systemic DNA damage responses: organismal adaptations to genome instability.
Review in Trends in genetics : TIG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Gonad-soma inter-tissue communication alleviates ultraviolet-induced neurotoxicity in C. elegans.Cell communication and signaling : CCS · 2026Article
- The impact of rearing environment on C. elegans: phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats.Biology open · 2026Article
- From Genome to Geroscience: How DNA Damage Shapes Systemic Decline.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Identification of long non-coding RNA and circular RNA associated networks in cellular stress responses.Frontiers in genetics · 2023Article
- Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans.Frontiers in aging · 2022Review
- Low dose ionizing radiation effects on the immune system.Environment international · 2021Review
- Ionizing radiation-induced circulatory and metabolic diseases.Environment international · 2021Review
- Kinetochore-independent mechanisms of sister chromosome separation.PLoS genetics · 2021Article
- SIRT1 modulates cell cycle progression by regulating CHK2 acetylation-phosphorylation.Cell death and differentiation · 2020Article
- DNA damage responses in ageing.Open biology · 2019Review
- Linking cellular stress responses to systemic homeostasis.Nature reviews. Molecular cell biology · 2018Review
- Integrating the DNA damage and protein stress responses during cancer development and treatment.The Journal of pathology · 2018Review
- ATM inhibition prevents interleukin-6 from contributing to the proliferation of glioblastoma cells after ionizing radiation.Journal of neuro-oncology · 2018Article
- DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity.Mechanisms of ageing and development · 2017Review
- The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation.The Journal of cell biology · 2017Article
- Septic Shock and the Aging Process: A Molecular Comparison.Frontiers in immunology · 2017Article
- Genotoxic properties of XLR-11, a widely consumed synthetic cannabinoid, and of the benzoyl indole RCS-4.Archives of toxicology · 2016Article
- Systemic DNA damage responses in aging and diseases.Seminars in cancer biology · 2016Review
- DNA Damage Response and Immune Defense: Links and Mechanisms.Frontiers in genetics · 2016Review
- Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.Seminars in cancer biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
DNA damage checkpoints are important tumor-suppressor mechanisms that halt cell cycle progression to allow time for DNA repair, or induce senescence and apoptosis to remove damaged cells permanently. Non-cell-autonomous DNA damage responses activate the innate immune system in multiple metazoan species. These responses not only enable clearance of damaged cells and contribute to tissue remodeling and regeneration but can also result in chronic inflammation and tissue damage. Germline DNA damage-induced systemic stress resistance (GDISR) is mediated by an ancestral innate immune response and results in organismal adjustments to the presence of damaged cells. We discuss GDISR as an organismal DNA damage checkpoint mechanism through which elevated somatic endurance can extend reproductive lifespan when germ cells require extended time for restoring genome stability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.