ArticleBiomaterials2014
Systemic oxygen delivery by peritoneal perfusion of oxygen microbubbles.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- Organic Sonosensitizers-based SDT with enhanced ROS generation.Ultrasonics sonochemistry · 2025Review
- Culture Medium Enriched with Ultrafine Carbon Monoxide Bubbles Enhances In Vitro Blastocyst Formation of In Vivo-Fertilized Mouse Zygotes.Antioxidants (Basel, Switzerland) · 2025Article
- Effect of Lipid Composition and Stirring Dynamics on Oxygen Microbubble Stability and Oxygen Release.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine.Nature biomedical engineering · 2024Article
- Peritoneal Infusion of Oxygen Microbubbles Alters the Metabolomic Profile of the Lung and Spleen in Acute Hypoxic Exposure.Bioengineering (Basel, Switzerland) · 2024Article
- Intraperitoneal oxygen microbubble therapy: A novel approach to enhance systemic oxygenation in a smoke inhalation model of acute hypoxic respiratory failure.Surgery open science · 2023Article
- Colonic oxygen microbubbles augment systemic oxygenation and COIntensive care medicine experimental · 2023Article
- Article
- Review
- Peritoneal Oxygenation as a Novel Technique for Extrapulmonary Ventilation; A Review and Discussion of the Literature.Advances in respiratory medicine · 2022Review
- Determination of oxygen relaxivity in oxygen nanobubbles at 3 and 7 Tesla.Magma (New York, N.Y.) · 2022Article
- Testing oxygenated microbubbles via intraperitoneal and intrathoracic routes on a large pig model of LPS-induced acute respiratory distress syndrome.Physiological reports · 2022Article
- Development of quantitative and concise measurement method of oxygen in fine bubble dispersion.PloS one · 2022Article
- Can Ultrasound-Guided Xenon Delivery Provide Neuroprotection in Traumatic Brain Injury?Neurotrauma reports · 2022Article
- Multivariable Dependence of Acoustic Contrast of Fluorocarbon and Xenon Microbubbles under Flow.Ultrasound in medicine & biology · 2021Article
- Artificial intelligence and guidance of medicine in the bubble.Cell & bioscience · 2021Article
- Ultrasound Responsive Noble Gas Microbubbles for Applications in Image-Guided Gas Delivery.Advanced healthcare materials · 2020Article
- Phospholipid Oxygen Microbubbles for Image-Guided Therapy.Nanotheranostics · 2020Article
- Magnetic resonance imaging of oxygen microbubbles.Healthcare technology letters · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe hypoxemia refractory to pulmonary mechanical ventilation remains life-threatening in critically ill patients. Peritoneal ventilation has long been desired for extrapulmonary oxygenation owing to easy access of the peritoneal cavity for catheterization and the relative safety compared to an extracorporeal circuit. Unfortunately, prior attempts involving direct oxygen ventilation or aqueous perfusates of fluorocarbons or hemoglobin carriers have failed, leading many researchers to abandon the method. We attribute these prior failures to limited mass transfer of oxygen to the peritoneum and have designed an oxygen formulation that overcomes this limitation. Using phospholipid-coated oxygen microbubbles (OMBs), we demonstrate 100% survival for rats experiencing acute lung trauma to at least 2 h. In contrast, all untreated rats and rats treated with peritoneal oxygenated saline died within 30 min. For rats treated with OMBs, hemoglobin saturation and heart rate were at normal levels over the 2-h timeframe. Peritoneal oxygenation with OMBs was therefore shown to be safe and effective, and the method requires less equipment and technical expertise than initiating and maintaining an extracorporeal circuit. Further translation of peritoneal oxygenation with OMBs may provide therapy for acute respiratory distress syndrome arising from trauma, sepsis, pneumonia, aspiration, burns and other pulmonary diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.