ArticleBiomaterials2014
Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Using tunable hydrogel microparticles to measure cellular forces.Nature protocols · 2026Review
- Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Electrografting a Hybrid Bilayer Membrane via Diazonium Chemistry for Electrochemical Impedance Spectroscopy of Amyloid-β Aggregation.Micromachines · 2022Article
- Substrate Resistance to Traction Forces Controls Fibroblast Polarization.Biophysical journal · 2020Article
- The Impact of Engineered Silver Nanomaterials on the Immune System.Nanomaterials (Basel, Switzerland) · 2020Review
- Collective tumor cell migration in the presence of fibroblasts.Journal of biomechanics · 2020Article
- Molecular clutch drives cell response to surface viscosity.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Concise Review: Fabrication, Customization, and Application of Cell Mimicking Microparticles in Stem Cell Science.Stem cells translational medicine · 2018Review
- Nanostructured Lipid-based Films for Substrate Mediated Applications in Biotechnology.Advanced functional materials · 2018Article
- Supported lipid bilayer platforms to probe cell mechanobiology.Biochimica et biophysica acta. Biomembranes · 2017Review
- Microfabricated tissues for investigating traction forces involved in cell migration and tissue morphogenesis.Cellular and molecular life sciences : CMLS · 2017Review
- Multi-Stacked Supported Lipid Bilayer Micropatterning through Polymer Stencil Lift-Off.Membranes · 2015Article
- Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks.Acta biomaterialia · 2015Article
- Autonomous buckling of micrometer-sized lipid-protein membrane patches constructed by Dictyostelium discoideum.Journal of biological engineering · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cell behavior such as cell adhesion, spreading, and contraction critically depends on the elastic properties of the extracellular matrix. It is not known, however, how cells respond to viscoelastic or plastic material properties that more closely resemble the mechanical environment cells encounter in the body. In this report, we employ viscoelastic and plastic biomembrane-mimicking cell substrates. The compliance of the substrates can be tuned by increasing the number of polymer-tethered bilayers. This leaves the density and conformation of adhesive ligands on the top bilayer unaltered. We then observe the response of fibroblasts to these property changes. For comparison, we also study the cells on soft polyacrylamide and hard glass surfaces. Cell morphology, motility, cell stiffness, contractile forces and adhesive contact size all decrease on more compliant matrices but are less sensitive to changes in matrix dissipative properties. These data suggest that cells are able to feel and respond predominantly to the effective matrix compliance, which arises as a combination of substrate and adhesive ligand mechanical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.