Evidence map›Paper›PMID 24439368›Full record

ReviewCell2014

What we talk about when we talk about fat.

Evan D Rosen, Bruce M Spiegelman

Abstract readReview
In one paragraph

Review in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,354 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,354citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,354 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Exercise and Fat: A Primer.Sports medicine - open · 2026
    Review
  19. Article
  20. Effect of Combined Grape Seed (International journal of molecular sciences · 2026
    Article

1,294 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Evan D RosenDivision of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Departments of Genetics and Cell Biology, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: erosen@bidmc.harvard.edu.
Bruce M SpiegelmanDepartments of Genetics and Cell Biology, Harvard Medical School, Boston, MA 02215, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: bruce_spiegelman@dfci.harvard.edu.

Funding

REGULATION OF NUTRIENT HOMEOSTASIS BY IRF4R01DK085171 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, EVAN D · 2010 to 2018
$3.7M
Epigenomics of Human Insulin ResistanceR01DK087092 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, EVAN D · 2009 to 2013
$3.3M
NIDDK NIH HHS R01 DK085171NIDDK NIH HHS R01 DK087092
6 · The paper itself

Abstract

There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify adipocytes and how we view adipose development and differentiation. We have new perspective on the roles played by adipocytes in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues. Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.

Indexed as

Lipid MetabolismAdipocytesAdipogenesisAnimalsHumansObesity

Identifiers

PMID24439368
PMCPMC3934003

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.