ArticleAcademic radiology2014
Blood flow reduction in breast tissue due to mammographic compression.
Article in Academic radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06360809 (Prehabilitation Exercise Program in Breast Cancer), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prehabilitation Exercise Program in Breast Cancer: Effects on Quality of Life and Tumor Microenvironment (PEP_BC)
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Monte Carlo simulation of spatial frequency domain imaging for breast tumors during compression.Journal of biomedical optics · 2024Article
- In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density.Scientific reports · 2024Article
- Functional hemodynamic imaging markers for the prediction of pathological outcomes in breast cancer patients treated with neoadjuvant chemotherapy.Journal of biomedical optics · 2024Article
- Global trends of cancer: The role of diet, lifestyle, and environmental factors.Cancer innovation · 2023Review
- In Vivo Validation of Diffuse Optical Imaging with a Dual-Direction Measuring Module of Parallel-Plate Architecture for Breast Tumor Detection.Biomedicines · 2022Article
- Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.Journal of biomedical optics · 2019Article
- Laser safety in fiber-optic monitoring of spinal cord hemodynamics: a preclinical evaluation.Journal of biomedical optics · 2018Article
- Influence of breast compression pressure on the performance of population-based mammography screening.Breast cancer research : BCR · 2017Article
- Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy.Physics in medicine and biology · 2017Article
- Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI).Biomedical optics express · 2017Article
- Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography.Journal of biomedical optics · 2016Article
- Alignment of sources and detectors on breast surface for noncontact diffuse correlation tomography of breast tumors.Applied optics · 2015Article
- Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity.Biomedical optics express · 2015Article
- Modified Beer-Lambert law for blood flow.Biomedical optics express · 2014Article
- Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
RATIONALE AND
objectivesThis study measures hemodynamic properties such as blood flow and hemoglobin concentration and oxygenation in the healthy human breast under a wide range of compressive loads. Because many breast-imaging technologies derive contrast from the deformed breast, these load-dependent vascular responses affect contrast agent-enhanced and hemoglobin-based breast imaging.
methodsDiffuse optical and diffuse correlation spectroscopies were used to measure the concentrations of oxygenated and deoxygenated hemoglobin, lipid, water, and microvascular blood flow during axial breast compression in the parallel-plate transmission geometry.
resultsSignificant reductions (P < .01) in total hemoglobin concentration (∼30%), blood oxygenation (∼20%), and blood flow (∼87%) were observed under applied pressures (forces) of up to 30 kPa (120 N) in 15 subjects. Lipid and water concentrations changed <10%.
conclusionsImaging protocols based on injected contrast agents should account for variation in tissue blood flow due to mammographic compression. Similarly, imaging techniques that depend on endogenous blood contrasts will be affected by breast compression during imaging.
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Registered trials
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