ArticleAcademic radiology2014
Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI.
Article in Academic radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Advances in translational imaging of the microcirculation.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Effect and correction of optode coupling errors in breast imaging using diffuse optical tomography.Biomedical optics express · 2021Article
- Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.Journal of biomedical optics · 2019Article
- Addition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis.Breast cancer research : BCR · 2017Article
- Breast density quantification using structured-light-based diffuse optical tomography simulations.Applied optics · 2017Article
- Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer.International journal of nanomedicine · 2017Article
- Alignment of sources and detectors on breast surface for noncontact diffuse correlation tomography of breast tumors.Applied optics · 2015Article
- Direct regularization from co-registered anatomical images for MRI-guided near-infrared spectral tomographic image reconstruction.Biomedical optics express · 2015Article
- MR-Guided Near-Infrared Spectral Tomography Increases Diagnostic Performance of Breast MRI.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Optimization of image reconstruction for magnetic resonance imaging-guided near-infrared diffuse optical spectroscopy in breast.Journal of biomedical optics · 2015Article
- Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance.Biomedical optics express · 2014Article
- Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging.Journal of biomedical optics · 2014Article
- Comparison of magnetic resonance imaging-compatible optical detectors for in-magnet tissue spectroscopy: photodiodes versus silicon photomultipliers.Journal of biomedical optics · 2014Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
RATIONALE AND
objectivesNear-infrared spectroscopy (NIRS) of breast can provide functional information on the vascular and structural compartments of tissues in regions identified during simultaneous magnetic resonance imaging (MRI). NIRS can be acquired during dynamic contrast-enhanced MRI (DCE-MRI) to accomplish image-guided spectroscopy of the enhancing regions, potentially increasing the diagnostic specificity of the examination and reducing the number of biopsies performed as a result of inconclusive MRI breast imaging studies. MATERIALS AND
methodsWe combine synergistic attributes of concurrent DCE-MRI and NIRS with a new design of the clinical NIRS breast interface that couples to a standard MR breast coil and allows imaging of variable breast sizes. Spectral information from healthy volunteers and cancer patients is recovered, providing molecular information in regions defined by the segmented MR image volume.
resultsThe new coupling system significantly improves examination utility by allowing improved coupling of the NIR fibers to breasts of all cup sizes and lesion locations. This improvement is demonstrated over a range of breast sizes (cup size A through D) and normal tissue heterogeneity using a group of eight healthy volunteers and two cancer patients. Lesions located in the axillary region and medial-posterior breast are now accessible to NIRS optodes. Reconstructed images were found to have biologically plausible hemoglobin content, oxygen saturation, and water and lipid fractions.
conclusionsIn summary, a new NIRS/MRI breast interface was developed to accommodate the variation in breast sizes and lesion locations that can be expected in clinical practice. DCE-MRI-guided NIRS quantifies total hemoglobin, oxygenation, and scattering in MR-enhancing regions, increasing the diagnostic information acquired from MR examinations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.