Evidence map›Paper›PMID 24439242›Full record

ArticleMetabolism: clinical and experimental2014

Multiple short bouts of exercise over 12-h period reduce glucose excursions more than an energy-matched single bout of exercise.

Michael Holmstrup, Timothy Fairchild, Stefan Keslacy, Ruth Weinstock, Jill Kanaley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  6. Interventions for reducing sedentary behaviour in people with stroke.The Cochrane database of systematic reviews · 2021
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  18. The Impact of Physical Activity in Patients With Type 2 Diabetes.American journal of lifestyle medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael HolmstrupDepartment of Exercise Science, Syracuse University, Syracuse, NY, USA; Department of Exercise and Rehabilitative Sciences, Slippery Rock University, Slippery Rock, PA, USA.
Timothy FairchildSchool of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia.
Stefan KeslacyDepartment of Exercise Science, Syracuse University, Syracuse, NY, USA.
Ruth WeinstockDepartment of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Jill KanaleyDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA. Electronic address: kanaleyj@missouri.edu.

Funding

Meal Frequency/Composition Effects on Insulin Resistence in Obese IndividualsR21DK084467 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI KANALEY, JILL A · 2009 to 2010
$401k
NIDDK NIH HHS R21 DK084467NIDDK NIH HHS R21DK084467-01
6 · The paper itself

Abstract

objectiveLong, uninterrupted bouts of sedentary behavior are thought to negatively influence postprandial glucose and insulin concentrations. We examined the effects of a 1-h bout of morning exercise versus intermittent walking bouts of short duration on glucose excursions and insulin secretion over 12-h. MATERIALS/

methodsEleven young, obese individuals (18-35 years, BMI>30kg/m(2)) with impaired glucose tolerance were studied on three 12-h study days: 1) sedentary behavior (SED); 2) sedentary behavior with 1-h morning exercise (EX) at 60%-65% VO2peak; and 3) sedentary behavior with 12-hourly, 5-min intervals of exercise (INT) at 60%-65% VO2peak. Meals (1046kJ/meal) were provided every 2-h. Blood samples were collected every 10 min and measured for glucose, insulin, and c-peptide concentrations.

resultsGlucose iAUC (12-h) was attenuated in the INT and SED conditions compared to the EX condition (P<0.05). Glucose concentrations were higher in the EX compared to the SED condition for ~150min (20% of the study day), and comparison of the EX-INT study days revealed that glucose concentrations were greater for~240min (~1/3 of the 12-hday). In the SED condition, the 12-h insulin iAUC was ~15% higher (P<0.05) compared to the INT and EX conditions. Insulin production rate was found to increase ~20% with INT exercise vs. the SED and EX condition (P<0.05).

conclusionsShort, frequent periods of exercise attenuated glucose excursions and insulin concentrations in obese individuals to a greater degree than an equal amount of exercise performed continuously in the morning.

Indexed as

ExerciseAdolescentAdultArea Under CurveBlood GlucoseBody Mass IndexFemaleGlucose Tolerance TestHumansInsulinMaleObesityYoung AdultBlood GlucoseInsulinGlucoseInsulinObesityPhysical activitySedentary

Identifiers

PMID24439242
PMCPMC3965589

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.