ArticleJournal of cardiology2014
Effect of treadmill training on endothelial function and walking abilities in patients with peripheral arterial disease.
Article in Journal of cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)
Influence of Different Types of Exercise Training on Selected Cardiovascular Parameters in Individuals With Peripheral Arterial Disease
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Exercise Training Improves Brachial Artery Endothelial Function, but Does Not Alter Inflammatory Biomarkers in Patients with Peripheral Artery Disease: a Systematic Review and Meta-analysis.Journal of cardiovascular translational research · 2024Pooled it
- Sarcopenia and peripheral arterial disease: a systematic review.Journal of cachexia, sarcopenia and muscle · 2020Pooled it
- The Effects of Cardiac Rehabilitation including Nordic Walking in Patients with Chronic Coronary Syndromes after Percutaneous Coronary Interventions in Elective Mode.Medicina (Kaunas, Lithuania) · 2023Trial
- Changes in vascular and inflammatory biomarkers after exercise rehabilitation in patients with symptomatic peripheral artery disease.Journal of vascular surgery · 2019Trial
- Step-monitored home exercise improves ambulation, vascular function, and inflammation in symptomatic patients with peripheral artery disease: a randomized controlled trial.Journal of the American Heart Association · 2014Trial
- Submaximal walking increases MicroRNA-126 and angiogenic markers in men and women with peripheral arterial disease.European journal of applied physiology · 2026Article
- Exercise-Based Cardiac Rehabilitation for Peripheral Artery Disease.Journal of clinical medicine · 2026Review
- Is It Possible to Train the Endothelium?-A Narrative Literature Review.Life (Basel, Switzerland) · 2024Review
- Stimulation of the Vascular Endothelium and Angiogenesis by Blood-Flow-Restricted Exercise.International journal of environmental research and public health · 2022Article
- Endothelial Function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the Evaluation of the Cardiovascular System.International journal of environmental research and public health · 2022Review
- Cardiac Rehabilitation in Patients with Peripheral Artery Disease-A Literature Review in COVID-19 Era.Journal of clinical medicine · 2022Review
- Does a Course of Aerobic Training Affect the Inflammatory Status and Cardiometabolic Risk Factors of Hookah-smoker Women? Results of a Cross-sectional Study.Addiction & health · 2022Article
- Article
- Patients with Diabetes Complicated by Peripheral Artery Disease: the Current State of Knowledge on Physiotherapy Interventions.Journal of diabetes research · 2021Review
- Paraoxonase-1 and Simvastatin Treatment in Patients with Stable Coronary Artery Disease.International journal of vascular medicine · 2016Article
- Exploring Vascular Function Biomarkers: Implications for Rehabilitation.Brazilian journal of cardiovascular surgeryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this prospective study we evaluated the effects of treadmill training on patients' walking ability, as well as endothelial function, high-sensitivity C-reactive protein (hs-CRP), and fibrinogen concentration.
methodsA total of 67 patients with stable intermittent claudication were included in a 12-week supervised training program. An observational follow-up period then lasted a mean of 37 weeks. Forty patients completed follow-up. Changes in blood pressure, flow-mediated dilatation (FMD), and treadmill walking performance expressed as maximal walking time (MWT) were assessed before and after the training program and during the follow-up period. Moreover, ankle/brachial index (ABI), plasma levels of hs-CRP, fibrinogen, as well as a lipid profile were assessed before and after the training program.
resultsMaximal walking time improved significantly after treadmill training by 90% (p<0.001) and after follow-up by 64% (p<0.001) in comparison to baseline. FMD values increased by 43% (p<0.001) after the training program, and by 29% (p=0.058) after follow-up, compared to baseline. We noticed a significant decrease in hs-CRP concentration (p=0.025) and an increase in ABI values (p=0.039) in response to the treadmill training program. No effect on lipid profile was observed.
conclusionsThe 12-week treadmill training program prolonged the asymptomatic walking distance. The improvement in FMD indicates a systemic effect of the treadmill program on endothelial function. The supervised treadmill training provides an effective and safe treatment option in patients with PAD. The effects of unsupervised exercise during follow-up period after treadmill programs remain tentative and underestimated.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.