ArticleValue in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
Use of Bayesian multivariate meta-analysis to estimate the HAQ for mapping onto the EQ-5D questionnaire in rheumatoid arthritis.
Article in Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Mapping health assessment questionnaire disability index onto EQ-5D-5L in China.Frontiers in public health · 2023Article
- A Bayesian Mixture Modelling of Stop Signal Reaction Time Distributions: The Second Contextual Solution for the Problem of Aftereffects of Inhibition on SSRT Estimations.Brain sciences · 2021Article
- Classifying information-sharing methods.BMC medical research methodology · 2021Article
- Bayesian Multiparameter Evidence Synthesis to Inform Decision Making: A Case Study in Metastatic Hormone-Refractory Prostate Cancer.Medical decision making : an international journal of the Society for Medical Decision Making · 2018Article
- Uncertainty in the Bayesian meta-analysis of normally distributed surrogate endpoints.Statistical methods in medical research · 2017Article
- Methods for network meta-analysis of continuous outcomes using individual patient data: a case study in acupuncture for chronic pain.BMC medical research methodology · 2016Article
- Absolute or relative effects? Arm-based synthesis of trial data.Research synthesis methods · 2016Article
- Social implications of rheumatic diseases.Reumatologia · 2016Review
- Get real in individual participant data (IPD) meta-analysis: a review of the methodology.Research synthesis methods · 2015Review
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7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn health technology assessment, decisions about reimbursement for new health technologies are largely based on effectiveness estimates. Sometimes, however, the target effectiveness estimates are not readily available. This may be because many alternative instruments measuring these outcomes are being used (and not all always reported) or an extended follow-up time of clinical trials is needed to evaluate long-term end points, leading to the limited data on the target clinical outcome. In the areas of highest priority in health care, decisions are required to be made on a short time scale. Therefore, alternative clinical outcomes, including surrogate end points, are increasingly being considered for use in evidence synthesis as part of economic evaluation.
objectiveTo illustrate the potential effect of reduced uncertainty around the clinical outcome on the utility when estimating it from a multivariate meta-analysis.
methodsBayesian multivariate meta-analysis has been used to synthesize data on correlated outcomes in rheumatoid arthritis and to incorporate external data in the model in the form of informative prior distributions. Estimates of Health Assessment Questionnaire were then mapped onto the health-related quality-of-life measure EuroQol five-dimensional questionnaire, and the effect was compared with mapping the Health Assessment Questionnaire obtained from the univariate approach.
resultsThe use of multivariate meta-analysis can lead to reduced uncertainty around the effectiveness parameter and ultimately uncertainty around the utility.
conclusionsBy allowing all the relevant data to be incorporated in estimating clinical effectiveness outcomes, multivariate meta-analysis can improve the estimation of health utilities estimated through mapping methods. While reduced uncertainty may have an effect on decisions based on economic evaluation of new health technologies, the use of short-term surrogate end points can allow for early decisions. More research is needed to determine the circumstances under which uncertainty is reduced.
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