ArticleBMC genomics2014
Massive deregulation of miRNAs from nuclear reprogramming errors during trophoblast differentiation for placentogenesis in cloned pregnancy.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health.International journal of molecular sciences · 2021Review
- Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas.Nature communications · 2020Article
- Maternal Recognition of Pregnancy in the Horse: Are MicroRNAs the Secret Messengers?International journal of molecular sciences · 2020Article
- The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer.Reproductive biology and endocrinology : RB&E · 2019Article
- Transcriptional defects and reprogramming barriers in somatic cell nuclear reprogramming as revealed by single-embryo RNA sequencing.BMC genomics · 2018Article
- Low levels of exosomal-miRNAs in maternal blood are associated with early pregnancy loss in cloned cattle.Scientific reports · 2017Article
- Coexpression analysis identifies nuclear reprogramming barriers of somatic cell nuclear transfer embryos.Oncotarget · 2017Article
- The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy.Clinical epigenetics · 2015Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow efficiency of Somatic Cell Nuclear Transfer (NT) has been widely addressed with high incidence of placental abnormalities due to genetic and epigenetic modifications. MiRNAs are shown to be major regulators of such modifications. The present study has been carried out to identify the expression patterns of 377 miRNAs, their functional associations and mechanism of regulation in bovine placentas derived from artificial insemination (AI), in vitro production (IVP) and NT pregnancies.
resultsThis study reveals a massive deregulation of miRNAs as chromosomal cluster or miRNA families without sex-linkage in NT and in-vitro derived IVP placentas. Cell specific localization miRNAs in blastocysts and expression profiling of embryos and placentas at different developmental stages identified that the major deregulation of miRNAs exhibited in placentas at day 50 of pregnancies is found to be less dependent on global DNA methylation, rather than on aberrant miRNA biogenesis molecules. Among them, aberrant AGO2 expression due to hypermethylation of its promoter was evident. Along with other factors, aberrant AGO2 expression was observed to be associated with multiple defects in trophoblast differentiation through deregulation of miRNAs mediated mechanisms.
conclusionThese aberrant miRNA activities might be associated with genetic and epigenetic modifications in abnormal placentogenesis due to maldifferentiation of early trophoblast cell lineage in NT and IVP pregnancies. This study provides the first insight into genome wide miRNA expression, their role in regulation of trophoblast differentiation as well as abnormal placental development in Somatic Cell Nuclear Transfer pregnancies to pave the way to improve the efficiency of cloning by nuclear transfer.
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