Evidence map›Paper›PMID 24438588›Full record

ArticleBMC genomics2014

Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.

Dan Zhou, Donghui Zhang, Guohui Ding, Linna Shi, Qing Hou, Yuting Ye, Yang Xu, Huayun Zhou, Chunrong Xiong, Shengdi Li and 12 more

Abstract read
In one paragraph

Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
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  5. Review
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  7. The algal selenoproteomes.BMC genomics · 2020
    Article
  8. Article
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  16. Biology, Bionomics and Molecular Biology ofFrontiers in microbiology · 2017
    Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Dan Zhou
Donghui Zhang
Guohui Ding
Linna Shi
Qing Hou
Yuting Ye
Yang Xu
Huayun Zhou
Chunrong Xiong
Shengdi Li
Jing Yu
Shanchao Hong
Xinyou Yu
Ping Zou
Chen Chen
Xuelian Chang
Weijie Wang
Yuan Lv
Yan Sun
Lei Ma
Bo ShenDepartment of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 210029, P,R, China. shenbo@njmu.edu.cn.
Changliang Zhu

Funding

Insecticide Resistance in Culex pipiens pallens MosquitoesR01AI075746 · NIAID · NANJING MEDICAL UNIVERSITY · PI ZHU, CHANGLIANG · 2008 to 2016
$795k
NIAID NIH HHS 2R01AI075746-05
6 · The paper itself

Abstract

backgroundAnopheles sinensis is an important mosquito vector of Plasmodium vivax, which is the most frequent and widely distributed cause of recurring malaria throughout Asia, and particularly in China, Korea, and Japan.

resultsWe performed 454 next-generation sequencing and obtained a draft sequence of A. sinensis assembled into scaffolds spanning 220.8 million base pairs. Analysis of this genome sequence, we observed expansion and contraction of several immune-related gene families in anopheline relative to culicine mosquito species. These differences suggest that species-specific immune responses to Plasmodium invasion underpin the biological differences in susceptibility to Plasmodium infection that characterize these two mosquito subfamilies.

conclusionsThe A. sinensis genome produced in this study, provides an important resource for analyzing the genetic basis of susceptibility and resistance of mosquitoes to Plasmodium parasites research which will ultimately facilitate the design of urgently needed interventions against this debilitating mosquito-borne disease.

Indexed as

GenomeAnimalsAnophelesChromosome MappingHigh-Throughput Nucleotide SequencingHumansInsect VectorsInterspersed Repetitive SequencesMalariaPhylogenyPlasmodium

Identifiers

PMID24438588
PMCPMC3901762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.