ReviewAddiction (Abingdon, England)2014
Cannabis controversies: how genetics can inform the study of comorbidity.
Review in Addiction (Abingdon, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Development of Substance Use Problems: The Role of Adolescent Cannabis Age of Onset, Frequency of Use and Childhood Risk Factors.Research on child and adolescent psychopathology · 2026Article
- Hemp Seed Cake Flour as a Source of Proteins, Minerals and Polyphenols and Its Impact on the Nutritional, Sensorial and Technological Quality of Bread.Foods (Basel, Switzerland) · 2023Article
- Alternative hypotheses regarding the association between early engagement in gambling and gambling-like activities and later problem gambling - a commentary on Richard and King (2023).Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues.Drug and alcohol dependence reports · 2022Article
- Examining Risk Factors in the Cannabis-Suicide Link: Considering Trauma and Impulsivity among University Students.International journal of environmental research and public health · 2022Article
- Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach.Drug and alcohol dependence · 2022Article
- Cannabis use and posttraumatic stress disorder: prospective evidence from a longitudinal study of veterans.Psychological medicine · 2022Observational
- Article
- Cannabis use and cannabis use disorder.Nature reviews. Disease primers · 2021Review
- Down and High: Reflections Regarding Depression and Cannabis.Frontiers in psychiatry · 2021Review
- Alcohol Use Disorder and the Persistence/Recurrence of Major Depression: Le trouble de l'usage de l'alcool et la persistance/récurrence de la dépression majeure.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Cannabis use is associated with lower rates of initiation of injection drug use among street-involved youth: A longitudinal analysis.Drug and alcohol review · 2018Article
- US Epidemiology of Cannabis Use and Associated Problems.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia.Biological psychiatry · 2017Article
- Cannabis and Depression: A Twin Model Approach to Co-morbidity.Behavior genetics · 2017Article
- Moderating effects of perceived social benefits on inhalant initiation among American Indian and White youth.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2016Article
- Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement.Frontiers in genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
aimsTo review three key and controversial comorbidities of cannabis use-other illicit drug use, psychosis and depression, as well as suicide, from a genetically informed perspective.
designSelective review.
resultsGenetic factors play a critical role in the association between cannabis use, particularly early-onset use and use of other illicit drugs, psychosis and depression, as well as suicide, albeit via differing mechanisms. For other illicit drugs, while there is strong evidence for shared genetic influences, residual association that is attributable to causal or person-specific environmental factors cannot be ruled out. For depression, common genetic influences are solely responsible for the association with cannabis use but for suicidal attempt, evidence for person-specific factors persists. Finally, even though rates of cannabis use are inordinately high in those with psychotic disorders, there is no evidence of shared genetic etiologies underlying this comorbidity. Instead, there is limited evidence that adolescent cannabis use might moderate the extent to which diathesis influences psychosis.
conclusionsOverlapping genetic influences underlie the association between early-onset cannabis use and other illicit drug use as well as depression and suicide. For psychosis, mechanisms other than shared genetic influences might be at play.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.