Trial reportNutrition journal2014
Effect of calcium phosphate and vitamin D₃ supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron.
Trial report in Nutrition journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01297023 (The Effect of Vitamin D3 Alone and in Combination With Calcium Phosphate on Bone Metabolism in Healthy Adults), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Vitamin D3 Alone and in Combination With Calcium Phosphate on Bone Metabolism in Healthy Adults
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Vitamin D and Bladder Cancer Risk: An Umbrella Review and Second Order Meta-Analysis.Cancer medicine · 2026Pooled it
- Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D.European journal of nutrition · 2021Pooled it
- The effect of vitamin D supplementation on hemoglobin concentration: a systematic review and meta-analysis.Nutrition journal · 2020Pooled it
- Pooled it
- Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- The Dose-Response Effects of Vitamin DNutrients · 2026Trial
- The effect of vitamin D supplementation on the muscle damage after eccentric exercise in young men: a randomized, control trial.Journal of the International Society of Sports Nutrition · 2020Trial
- Non-Compartmental Pharmacokinetics and Safety of Single-Dose Eldecalcitol (ED-71) in Healthy Chinese Adult Males.Clinical drug investigation · 2018Trial
- High phosphorus intake and gut-related parameters - results of a randomized placebo-controlled human intervention study.Nutrition journal · 2018Trial
- Consequences of a high phosphorus intake on mineral metabolism and bone remodeling in dependence of calcium intake in healthy subjects - a randomized placebo-controlled human intervention study.Nutrition journal · 2016Trial
- Relationship between Bladder Cancer, Nutritional Supply, and Treatment Strategies: A Comprehensive Review.Nutrients · 2023Review
- Fortification of Staple Foods for Household Use with Vitamin D: An Overview of Systematic Reviews.Nutrients · 2023Review
- Dietary iron intake and its impact on osteopenia/osteoporosis.BMC endocrine disorders · 2023Article
- Interactions between FGF23 and vitamin D.Endocrine connections · 2022Review
- Effect of Dietary Supplementation with Calcium, Phosphorus and Vitamin DAnimals : an open access journal from MDPI · 2022Article
- Diet Modulates the Effects of Genetic Variants on the Vitamin D Metabolic Pathway and Bone Mineral Density in Mexican Postmenopausal Women.The Journal of nutrition · 2021Article
- Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D₃.International journal of molecular sciences · 2019Article
- Habitual Intakes, Food Sources and Excretions of Phosphorus and Calcium in Three German Study Collectives.Nutrients · 2018Article
- Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis.Breast cancer research and treatment · 2017Article
- Effect of vitamin DBone reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to determine the effect of calcium phosphate and/or vitamin D₃ on bone and mineral metabolism.
methodsSixty omnivorous healthy subjects participated in the double-blind, placebo-controlled parallel designed study. Supplements were tricalcium phosphate (CaP) and cholecalciferol (vitamin D₃). At the beginning of the study (baseline), all subjects documented their normal nutritional habits in a dietary record for three successive days. After baseline, subjects were allocated to three intervention groups: CaP (additional 1 g calcium/d), vitamin D₃ (additional 10 μg/d) and CaP + vitamin D₃. In the first two weeks, all groups consumed placebo bread, and afterwards, for eight weeks, the test bread according to the intervention group. In the last week of each study period (baseline, placebo, after four and eight weeks of intervention), a faecal (three days) and a urine (24 h) collection and a fasting blood sampling took place. Calcium, phosphorus, magnesium and iron were determined in faeces, urine and blood. Bone formation and resorption markers were analysed in blood and urine.
resultsAfter four and eight weeks, CaP and CaP + vitamin D₃ supplementations increased faecal excretion of calcium and phosphorus significantly compared to placebo. Due to the vitamin D₃ supplementations (vitamin D₃, CaP + vitamin D₃), the plasma 25-(OH)D concentration significantly increased after eight weeks compared to placebo. The additional application of CaP led to a significant increase of the 25-(OH)D concentration already after four weeks. Bone resorption and bone formation markers were not influenced by any intervention.
conclusionsSupplementation with daily 10 μg vitamin D₃ significantly increases plasma 25-(OH)D concentration. The combination with daily 1 g calcium (as CaP) has a further increasing effect on the 25-(OH)D concentration. Both CaP alone and in combination with vitamin D₃ have no beneficial effect on bone remodelling markers and on the metabolism of calcium, phosphorus, magnesium and iron.
trial registrationNCT01297023.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.