ArticleAJNR. American journal of neuroradiology2014
Association of white matter hyperintensities with low serum 25-hydroxyvitamin D levels.
Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Impact of 25-Hydroxy Vitamin D on White Matter Hyperintensity in Elderly Patients: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Association of serum 25-hydroxyvitamin D and homocysteine "double-risk" status with executive dysfunction in older adults with hypertension.Frontiers in nutrition · 2025Article
- The dilemma of bright spots detected on magnetic resonance imaging of the brain for the diagnosis of multiple sclerosis: A retrospective evaluation of nonspecific white matter lesions.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2024Article
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- Evaluation of white matter integrity by diffusion tensor imaging in the deficiencies of vitamin B12 and folate in older patients.The British journal of radiology · 2023Article
- Brain changes in neuroimaging of adult patients with vitamin D deficiency: systematic review protocol.BMJ open · 2023Article
- Corrigendum: Vitamin D, Folate, and Cobalamin Serum Concentrations Are Related to Brain Volume and White Matter Integrity in Urban Adults.Frontiers in aging neuroscience · 2021Article
- Vitamin D, Folate, and Cobalamin Serum Concentrations Are Related to Brain Volume and White Matter Integrity in Urban Adults.Frontiers in aging neuroscience · 2020Article
- Association of serum cystatin C with white matter abnormalities in patients with amnestic mild cognitive impairment.Geriatrics & gerontology international · 2019Article
- Vitamin D and Risk of Neuroimaging Abnormalities.PloS one · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeVitamin D deficiency is associated with cognitive impairment in the elderly and with increased white matter T2 hyperintensities in elderly debilitated patients. We investigated the relationship between serum vitamin D and brain MR findings in adult outpatients. MATERIALS AND
methodsBrain MR studies of 56 patients ages 30-69 years were selected when vitamin D level had been obtained within 90 days of the MRI. White matter T2 hyperintensities were characterized by size and location by two neuroradiologists. Manual volumetric analysis was assessed in patients more than 50 years of age.
resultsThe entire cohort showed a significant negative relationship between serum 25-hydroxyvitamin D and the number of confluent juxtacortical white matter T2 hyperintensities (P = .047). The cohort ages 50 years and older showed stronger correlation between confluent white matter T2 hyperintensities and serum 25-hydroxyvitamin D in the juxtacortical region; number (P = .015) and size of white matter T2 hyperintensities (P = .048). Atrophy was not significantly related to serum 25-hydroxyvitamin D by radiologist visual analysis or by the bicaudate ratio.
conclusionsWe found a significant relationship between vitamin D and white matter T2 hyperintensities in independent adult outpatients, especially over the age of 50 years.
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