ArticleThe oncologist2014
New insights into the molecular pathogenesis of langerhans cell histiocytosis.
Article in The oncologist, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Radiological assessment of extremity bone involvement in Erdheim-Chester disease: a systematic review of case reports.Skeletal radiology · 2025Pooled it
- Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics.Cancer metastasis reviews · 2026Review
- Predictive value of metabolic parameters from PET/CT in adult multifocal Langerhans cell histiocytosis.Annals of nuclear medicine · 2026Article
- BRAFLeukemia · 2023Article
- Langerhans cell histiocytosis: current advances in molecular pathogenesis.Frontiers in immunology · 2023Review
- Case report: Common clonal origin of concurrent langerhans cell histiocytosis and acute myeloid leukemia.Frontiers in oncology · 2022Article
- Adult-onset perianal Langerhans cell histiocytosis presenting as pruritus ani: a case report and review of the literature.Journal of medical case reports · 2021Review
- Epiphyseal lymphoid infiltrates of the knee in adolescents.Skeletal radiology · 2021Article
- Immune Microenvironment in Langerhans Cell Histiocytosis: Potential Prognostic Indicators.Frontiers in oncology · 2021Article
- Article
- Langerhans Cell Histiocytosis with Isolated Cutaneous Involvement Refractory to Polychemotherapy: A Case Report.The Journal of clinical and aesthetic dermatology · 2020Article
- Incidence and radiological pattern of eosinophilic granuloma: a retrospective study in a Chinese tertiary hospital.Journal of orthopaedic surgery and research · 2019Article
- Diverse cutaneous manifestation of Langerhans cell histiocytosis: a 10-year retrospective cohort study.European journal of pediatrics · 2019Article
- Altered Populations of Unconventional T Cell Lineages in Patients with Langerhans Cell Histiocytosis.Scientific reports · 2018Article
- Review
- Ninety-year-old man with hypereosinophilia, lymphadenopathies and pruritus.BMJ case reports · 2018Article
- The Dr. Jekyll and Mr. Hyde complexity of the macrophage response in disease.Journal of leukocyte biology · 2017Review
- An unusual case of adult-onset multi-systemic Langerhans cell histiocytosis with perianal and incident thyroid involvement.Endocrinology, diabetes & metabolism case reports · 2017Article
- Macrophages: Their Emerging Roles in Bone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Review
- Langerhans cell histiocytosis with multisystem involvement in an infant: A case report.Experimental and therapeutic medicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder characterized by an accumulation of cells sharing the major phenotypic features of cutaneous Langerhans cells. Given its variable clinical evolution, ranging from self-limiting lesions to multisystemic forms with a poor prognosis, in the last decades it has been debated whether LCH might not have a neoplastic rather than an inflammatory nature. However, although the fundamental events underlying the pathogenesis of LCH are still elusive, recent advances have strikingly improved our understanding of the disease. In particular, the identification of multiple interplays between LCH cells and their tumor microenvironment, along with the recognition of the lesional cytokine storm as a key determinant of LCH progression, has substantiated new opportunities for devising targeted therapeutic approaches. Strikingly, the detection of the rapidly accelerated fibrosarcoma isoform B(V600E) gain-of-function mutation as a genetic alteration recurring in more than 50% of patients has fueled the paradoxical picture of LCH as a tumor of the antigen-presenting cells that can evade rejection by the immune system. Thus, new evidence regarding the ontogeny of LCH cells, as well as a better understanding of the putative immune system frustrating strategy in LCH, may help to define the precise pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.