ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I. Impact of obesity.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
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- Chorioamnionitis exposure remodels the unique histone modification landscape of neonatal monocytes and alters the expression of immune pathway genes.The FEBS journal · 2019Article
- Obese rats supplemented with bitter melon display marked shifts in the expression of genes controlling inflammatory response and lipid metabolism by RNA-Seq analysis of colonic mucosa.Genes & genomics · 2018Article
- Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli.Physiological reviews · 2017Review
- Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Transcriptomic differences in intra-abdominal adipose tissue in extremely obese adolescents with different stages of NAFLD.Physiological genomics · 2016Article
- Impact of external pneumatic compression target inflation pressure on transcriptome-wide RNA expression in skeletal muscle.Physiological reports · 2016Article
- Exercise training improves vascular mitochondrial function.American journal of physiology. Heart and circulatory physiology · 2016Article
- Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Modulation of endothelial cell phenotype by physical activity: impact on obesity-related endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2015Review
- Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing.Physiological reports · 2015Article
- Identification of genes whose expression is altered by obesity throughout the arterial tree.Physiological genomics · 2014Article
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
We employed next-generation RNA sequencing (RNA-Seq) technology to determine the influence of obesity on global gene expression in skeletal muscle feed arteries. Transcriptional profiles of the gastrocnemius and soleus muscle feed arteries (GFA and SFA, respectively) and aortic endothelial cell-enriched samples from obese Otsuka Long-Evans Tokushima Fatty (OLETF) and lean Long-Evans Tokushima Otsuka (LETO) rats were examined. Obesity produced 282 upregulated and 133 downregulated genes in SFA and 163 upregulated and 77 downregulated genes in GFA [false discovery rate (FDR) < 10%] with an overlap of 93 genes between the arteries. In LETO rats, there were 89 upregulated and 114 downregulated genes in the GFA compared with the SFA. There were 244 upregulated and 275 downregulated genes in OLETF rats (FDR < 10%) in the GFA compared with the SFA, with an overlap of 76 differentially expressed genes common to both LETO and OLETF rats in both the GFA and SFA. A total of 396 transcripts were found to be differentially expressed between LETO and OLETF in aortic endothelial cell-enriched samples. Overall, we found 1) the existence of heterogeneity in the transcriptional profile of the SFA and GFA within healthy LETO rats, 2) that this between-vessel heterogeneity was markedly exacerbated in the hyperphagic, obese OLETF rat, and 3) a greater number of genes whose expression was altered by obesity in the SFA compared with the GFA. Also, results indicate that in OLETF rats the GFA takes on a relatively more proatherogenic phenotype compared with the SFA.
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