Evidence map›Paper›PMID 24436288›Full record

ArticleChembiochem : a European journal of chemical biology2014

Structure elucidation of DNA-protein crosslinks by using reductive desulfurization and liquid chromatography-tandem mass spectrometry.

Susith Wickramaratne, Natalia Y Tretyakova

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Susith WickramaratneUniversity of Minnesota Masonic Cancer Center and the Department of Chemistry, 2231 6th Street SE, Room 2-220 CCRB, Minneapolis, MN 55455 (USA).
Natalia Y Tretyakova
University of Minnesota · US

Funding

DNA Cross-Linking By DiepoxybutaneR01CA100670 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2021
$3.5M
NCI NIH HHS CA 100670NCI NIH HHS R01 CA100670
6 · The paper itself

Abstract

Easier with ethyl: Guengerich and co-workers have developed a powerful new approach to the structure elucidation of hydrolytically stable AGT-DNA crosslinks by reductive desulfurization of the thioether linkage between AGT and DNA to convert cysteine DPCs to the corresponding ethyl-DNA adducts, which can be readily characterized by LC-MSn.

Indexed as

Chromatography, High Pressure LiquidCysteineDNADNA AdductsGuanineO(6)-Methylguanine-DNA MethyltransferaseOxidation-ReductionSpectrometry, Mass, Electrospray IonizationSulfurCysteineDNADNA AdductsGuanineO(6)-Methylguanine-DNA MethyltransferaseSulfurdesulfurizationDNA-protein crosslinkslabile and nonlabile DNA adductsliquid chromatography-tandem mass spectrometryO6-alkylguanine DNA alkyltransferase

Identifiers

PMID24436288
PMCPMC4034465
OpenAlexW1988357961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.