ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2014
Cortical and trabecular bone benefits of mechanical loading are maintained long term in mice independent of ovariectomy.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Methodological aspects ofJournal of musculoskeletal & neuronal interactions · 2023Pooled it
- Linking microarchitectural deterioration to altered tissue-level mechanical environments in ovariectomized mouse femora.Scientific reports · 2026Article
- The skeletal transcriptional response to mechanical load varies with age and tissue compartment in female mice.JBMR plus · 2025Article
- Tartrate-resistant acid phosphatase augments the bone anabolic response to mechanical loading in male mice.JBMR plus · 2025Article
- Osseous morphology differences in the foot and ankle associated with Charcot-Marie-Tooth disease.JBMR plus · 2025Article
- Intermittent mechanical loading on mouse tibia accelerates longitudinal bone growth by inducing PTHrP expression in the female tibial growth plate.Physiological reports · 2024Article
- Predicting altered bone biomechanics in juvenile mice: insights from microgravity simulation, loading interventions, and Raman Spectroscopy.Laboratory animal research · 2024Article
- Treadmill Exercise Reverses the Change of Dendritic Morphology and Activates BNDF-mTOR Signaling Pathway in the Hippocampus and Cerebral Cortex of Ovariectomized Mice.Journal of molecular neuroscience : MN · 2021Article
- Preventive Moderate Continuous Running-Exercise Conditioning Improves the Healing of Non-Critical Size Bone Defects in Male Wistar Rats: A Pilot Study Using µCT.Life (Basel, Switzerland) · 2020Article
- Isolated Cyclic Loading During Adolescence Improves Tibial Bone Microstructure and Strength at Adulthood.JBMR plus · 2020Article
- Ontogenetic changes to bone microstructure in an archaeologically derived sample of human ribs.Journal of anatomy · 2020Article
- Lasting organ-level bone mechanoadaptation is unrelated to local strain.Science advances · 2020Article
- Multiscale experimental study on the effects of different weight-bearing levels during moderate treadmill exercise on bone quality in growing female rats.Biomedical engineering online · 2019Article
- Antiresorptive Agents are More Effective in Preventing Titanium Particle-Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short-Term Administration.Artificial organs · 2018Article
- Progressive skeletal benefits of physical activity when young as assessed at the midshaft humerus in male baseball players.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Article
- Physical Activity for Strengthening Fracture Prone Regions of the Proximal Femur.Current osteoporosis reports · 2017Review
- Estrogens and Androgens in Skeletal Physiology and Pathophysiology.Physiological reviews · 2017Review
- Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age.PloS one · 2017Article
- Bone Homeostasis and Repair: Forced Into Shape.Current rheumatology reports · 2015Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Skeletal loading enhances cortical and trabecular bone properties. How long these benefits last after loading cessation remains an unresolved, clinically relevant question. This study investigated long-term maintenance of loading-induced cortical and trabecular bone benefits in female C57BL/6 mice and the influence of a surgically induced menopause on the maintenance. Sixteen-week-old animals had their right tibia extrinsically loaded 3 days/week for 4 weeks using the mouse tibial axial compression loading model. Left tibias were not loaded and served as internal controls. Animals were subsequently detrained (restricted to cage activities) for 0, 4, 8, 26, or 52 weeks, with ovariectomy (OVX) or sham-OVX surgery being performed at 0 weeks detraining. Loading increased midshaft tibia cortical bone mass, size, and strength, and proximal tibia bone volume fraction. The cortical bone mass, area, and thickness benefits of loading were lost by 26 weeks of detraining because of heightened medullary expansion. However, loading-induced benefits on bone total area and strength were maintained at each detraining time point. Similarly, the benefits of loading on bone volume fraction persisted at all detraining time points. The long-term benefits of loading on both cortical and trabecular bone were not influenced by a surgically induced menopause because there were no interactions between loading and surgery. However, OVX had independent effects on cortical bone properties at early (4 and 8 weeks) detraining time points and trabecular bone properties at all detraining time points. These cumulative data indicate loading has long-term benefits on cortical bone size and strength (but not mass) and trabecular bone morphology, which are not influenced by a surgically induced menopause. This suggests skeletal loading associated with physical activity may provide long-term benefits by preparing the skeleton to offset both the cortical and trabecular bone changes associated with aging and menopause.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.