ArticleJournal of biomolecular NMR2014
Time-resolved multidimensional NMR with non-uniform sampling.
Article in Journal of biomolecular NMR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 104 citations in OpenAlex.
- Integrated Reaction Monitoring and In Situ Structural Elucidation of Reactive Intermediates With Time-Resolved NOAH NMR Supersequences.Magnetic resonance in chemistry : MRC · 2026Article
- Toward ultimate NMR resolution with deep learning.Science advances · 2026Article
- Solution Domain Dynamics of Monomeric SARS-CoV‑2 Main Protease Revealed by Optimized NMR Residual Dipolar Coupling Measurements.ACS physical chemistry Au · 2026Article
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- Simple Parameters and Data Processing for Better Signal-to-Noise and Temporal Resolution inThe Journal of organic chemistry · 2024Article
- nus-tool: A unified program for generating and analyzing sample schedules for nonuniformly sampled NMR experiments.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- Article
- Conformational Dynamics of Phytoglobin BvPgb1.2 fromInternational journal of molecular sciences · 2023Article
- Deeper Insight into Photopolymerization: The Synergy of Time-Resolved Nonuniform Sampling and Diffusion NMR.Journal of the American Chemical Society · 2022Article
- Unambiguous Tracking of Protein Phosphorylation by Fast High-Resolution FOSY NMR*.Angewandte Chemie (International ed. in English) · 2021Article
- Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1.EMBO reports · 2021Article
- Definition of the immune evasion-replication interface of rabies virus P protein.PLoS pathogens · 2021Article
- NMR Studies of Tau Protein in Tauopathies.Frontiers in molecular biosciences · 2021Review
- Article
- Accelerating Restricted Diffusion NMR Studies with Time-Resolved and Ultrafast Methods.Analytical chemistry · 2020Article
- Sensitivity-enhanced three-dimensional and carbon-detected two-dimensional NMR of proteins using hyperpolarized water.Journal of biomolecular NMR · 2020Article
- Article
- Importance of time-ordered non-uniform sampling of multi-dimensional NMR spectra of AβJournal of biomolecular NMR · 2019Article
- Time-domain signal modelling in multidimensional NMR experiments for estimation of relaxation parameters.Journal of biomolecular NMR · 2019Article
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time-resolved experiments demand high resolution both in spectral dimensions and in time of the studied kinetic process. The latter requirement traditionally prohibits applications of the multidimensional experiments, which, although capable of providing invaluable information about structure and dynamics and almost unlimited spectral resolution, require too lengthy data collection. Our work shows that the problem has a solution in using modern methods of NMR data collection and signal processing. A continuous fast pulsing three-dimensional experiment is acquired using non-uniform sampling during full time of the studied reaction. High sensitivity and time-resolution of a few minutes is achieved by simultaneous processing of the full data set with the multi-dimensional decomposition. The method is verified and illustrated in realistic simulations and by measuring deuterium exchange rates of amide protons in ubiquitin. We applied the method for characterizing kinetics of in vitro phosphorylation of two tyrosine residues in an intrinsically disordered cytosolic domain of the B cell receptor protein CD79b. Signals of many residues including tyrosines in both phosphorylated and unmodified forms of CD79b are found in a heavily crowded region of 2D ¹H-¹⁵N correlation spectrum and the significantly enhanced spectral resolution provided by the 3D time-resolved approach was essential for the quantitative site-specific analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.