ReviewCerebellum (London, England)2014
From neurons to neuron neighborhoods: the rewiring of the cerebellar cortex in essential tremor.
Review in Cerebellum (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21-Year Period.Annals of clinical and translational neurology · 2026Article
- Serum Neurofilament Light-Chain Levels in Essential Tremor: A Replication Study.Neuro-degenerative diseases · 2024Article
- Cerebellar Transcranial Alternating Current Stimulation in Essential Tremor Patients with Thalamic Stimulation: A Proof-of-Concept Study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Essential Tremor Within the Broader Context of Other Forms of Cerebellar Degeneration.Cerebellum (London, England) · 2020Review
- Essential tremor pathology: neurodegeneration and reorganization of neuronal connections.Nature reviews. Neurology · 2020Review
- Essential tremor: the most common form of cerebellar degeneration?Cerebellum & ataxias · 2020Review
- The cortico-rubral and cerebello-rubral pathways are topographically organized within the human red nucleus.Scientific reports · 2019Article
- Etiologic links between environmental and lifestyle factors and Essential tremor.Annals of clinical and translational neurology · 2019Review
- Oscillatory Cortical Activity in an Animal Model of Dystonia Caused by Cerebellar Dysfunction.Frontiers in cellular neuroscience · 2018Article
- Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection.Parasites & vectors · 2017Article
- Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures.Parkinsonism & related disorders · 2017Article
- Climbing fiber-Purkinje cell synaptic pathology in tremor and cerebellar degenerative diseases.Acta neuropathologica · 2017Article
- Identification of candidate genes for familial early-onset essential tremor.European journal of human genetics : EJHG · 2016Article
- Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome.Cerebellum (London, England) · 2016Review
- Linking Essential Tremor to the Cerebellum: Neuropathological Evidence.Cerebellum (London, England) · 2016Review
- The Role of β-Carboline Alkaloids in the Pathogenesis of Essential Tremor.Cerebellum (London, England) · 2016Review
- Essential Tremor: A Common Disorder of Purkinje Neurons?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2016Review
- Purkinje cell loss in essential tremor.Movement disorders : official journal of the Movement Disorder Society · 2014Article
- Essential tremor: from bedside to bench and back to bedside.Current opinion in neurology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Remarkably little has been written on the biology of essential tremor (ET), despite its high prevalence. The olivary model, first proposed in the 1970s, is the traditional disease model for ET; however, the model is problematic for a number of reasons. Recently, intensive tissue-based studies have identified a series of structural changes in the brains of most ET cases, and nearly all of the observed changes are located in the cerebellar cortex. These studies suggest that Purkinje cells are central to the pathogenesis of ET and may thus provide a focus for the development of novel therapeutic strategies. Arising from these studies, a new model of ET proposes that the population of Purkinje cells represents the site of the initial molecular/cellular events leading to ET. Furthermore, a number of secondary changes/remodeling observed in the molecular and granular layers (i.e., in the Purkinje cell "neighborhood") are likely to be of additional mechanistic importance. On a physiological level, the presence of remodeling indicates the likely formation of aberrant synapses and the creation of new/abnormal cortical circuits in ET. Specific efforts need to be devoted to understanding the cascade of biochemical and cellular events occurring in the Purkinje cell layer in ET and its neuron neighborhood, as well as the physiological effects of secondary remodeling/rewiring that are likely to be occurring in this brain region in ET.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.