ArticleThe Journal of clinical investigation1987
Gray platelet syndrome. Demonstration of alpha granule membranes that can fuse with the cell surface.
Article in The Journal of clinical investigation, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 104 citations in OpenAlex.
- Platelet α-granule cargo packaging and endocytosis are important for normal mouse skin wound healing.Blood advances · 2026Article
- Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets.Journal of clinical medicine · 2021Review
- A Deep Dive into the Pathology of Gray Platelet Syndrome: New Insights on Immune Dysregulation.Journal of blood medicine · 2021Review
- Modification of Pulsed Electric Field Conditions Results in Distinct Activation Profiles of Platelet-Rich Plasma.PloS one · 2016Article
- Article
- Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.The Journal of clinical investigation · 2013Article
- The Nbeal2(-/-) mouse as a model for the gray platelet syndrome.Rare diseases (Austin, Tex.) · 2013Article
- The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis.Blood · 2012Article
- T granules in human platelets function in TLR9 organization and signaling.The Journal of cell biology · 2012Article
- Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p.Blood · 2010Article
- [Congenital thrombocytopathies].Der Internist · 2010Review
- Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1.Thrombosis and haemostasis · 2008Article
- Pseudo gray platelet syndrome in a patient with acute myocardial infarction.International journal of hematology · 2002Article
- Gray platelet syndrome. Dissociation between abnormal sorting in megakaryocyte alpha-granules and normal sorting in Weibel-Palade bodies of endothelial cells.The Journal of clinical investigation · 1993Article
- P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells.The Journal of cell biology · 1992Article
- Platelets of the Wistar Furth rat have reduced levels of alpha-granule proteins. An animal model resembling gray platelet syndrome.The Journal of clinical investigation · 1991Article
- Decreased content and surface expression of alpha-granule membrane protein GMP-140 in one of two types of platelet alpha delta storage pool deficiency.The Journal of clinical investigation · 1991Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Platelets from patients with the gray platelet syndrome have decreased recognizable alpha granules and are markedly deficient in some alpha-granule secretory proteins. Using immunocytochemical techniques with antibodies to an alpha-granule membrane protein, GMP-140, we identified the membranes of intracellular vesicles in gray platelets as alpha-granule membranes. Gray platelets contained normal amounts of GMP-140 as measured by electroimmunoassay. The activation of gray platelets with thrombin caused GMP-140 to be redistributed to the plasma membrane surface, as in normal platelets. In agreement with previous studies, an endogenously synthesized secretory protein, platelet factor 4, was undetectable in gray platelets. However, the alpha-granule proteins albumin and IgG, which are thought to be derived from endocytosis of plasma proteins into megakaryocytes, were present in substantial quantities and were secreted efficiently from gray platelets. Therefore, the fundamental defect in the gray platelet syndrome may be in the targeting of endogenously synthesized secretory proteins to developing alpha granules in megakaryocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.