ReviewSocial psychiatry and psychiatric epidemiology2014
The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research.
Review in Social psychiatry and psychiatric epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.Molecular neurobiology · 2018Pooled it
- The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.PloS one · 2018Pooled it
- Ancestry-Calibrated Polygenic Risk Scores Predict PTSD Trajectories in Recent Trauma Survivors and Interact with Neighborhood Resources.medRxiv : the preprint server for health sciences · 2026Article
- Recent findings and future directions for the intersection of genetic and environmental contributions to schizophrenia.Genomic psychiatry : advancing science from genes to society · 2025Article
- Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period.Genes, brain, and behavior · 2023Article
- Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case-Control Study.Schizophrenia bulletin · 2022Article
- Associations Among Parental Caregiving Quality, Cannabinoid Receptor 1 Expression-Based Polygenic Scores, and Infant-Parent Attachment: Evidence for Differential Genetic Susceptibility?Frontiers in neuroscience · 2021Article
- Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness.Acta psychiatrica Scandinavica · 2020Article
- Neighborhood Characteristics at Birth and Positive and Negative Psychotic Symptoms in Adolescence: Findings From the ALSPAC Birth Cohort.Schizophrenia bulletin · 2020Article
- Genetic liability in individuals at ultra-high risk of psychosis: A comparison study of 9 psychiatric traits.PloS one · 2020Article
- Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms.Social psychiatry and psychiatric epidemiology · 2019Article
- A validation of the diathesis-stress model for depression in Generation Scotland.Translational psychiatry · 2019Article
- Psychosis Polyrisk Score (PPS) for the Detection of Individuals At-Risk and the Prediction of Their Outcomes.Frontiers in psychiatry · 2019Review
- Sensitivity to Peer Evaluation and Its Genetic and Environmental Determinants: Findings from a Population-Based Twin Study.Child psychiatry and human development · 2018Article
- Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders.The British journal of psychiatry : the journal of mental science · 2018Article
- What causes psychosis? An umbrella review of risk and protective factors.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2018Article
- A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Genome-wide association analysis identifies common variants influencing infant brain volumes.Translational psychiatry · 2017Article
- HDAC1 links early life stress to schizophrenia-like phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Prenatal genetic counselling for psychiatric disorders.Prenatal diagnosis · 2017Article
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Abstract
Schizophrenia is a devastating mental disorder. The level of risk in the general population is sustained by the persistence of social, environmental and biological factors, as well as their interactions. Socio-environmental risk factors for schizophrenia are well established and robust. The same can belatedly be said of genetic risk factors for the disorder. Recent progress in schizophrenia genetics is primarily fuelled by genome-wide association, which is able to leverage substantial proportions of additional explained variance previously classified as 'missing'. Here, we provide an outline of the emerging genetic landscape of schizophrenia and demonstrate how this knowledge can be turned into a simple empirical measure of genetic risk, known as a polygenic risk score. We highlight the statistical framework used to assess the clinical potential of the new score and finally, draw relevance to and discuss the clinical implications for the study of gene-environment interaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.