ArticlePsychosomatic medicine2014
Apolipoprotein E and depressive symptoms: shared or independent routes to age-related cognitive decline?
Article in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Life Course Pathways From Childhood Socioeconomic Status to Later-Life Cognition: Evidence From the Wisconsin Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
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1 author at 1 institution in 1 country.
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Abstract
Variation in the apolipoprotein E (APOE) genotype is associated with cognitive decline in normal aging. Increased symptoms of depression are also associated with greater cognitive impairment and risk of dementia in old age. Unlike APOE, where the direction of the effect is from genotype to cognitive decline, the causal relationship between depressed mood and cognitive impairment is not known. Rather than being a reaction to worsening cognitive performance with age, depressive symptoms might be a risk factor for age-related cognitive decline. The study by Rajan and colleagues (published in this issue of Psychosomatic Medicine) speaks to this possibility and, importantly, considers the association between depressive symptoms and age-related cognitive decline in the context of APOE variation. This editorial discusses these findings in relation to causal pathways and highlights how longitudinal studies of this nature will improve our understanding of the biological underpinnings of cognitive decline and classification of its risk in the general population.
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