ArticlePsychosomatic medicine2014
Gene-behavior interaction of depressive symptoms and the apolipoprotein E {varepsilon}4 allele on cognitive decline.
Article in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Affective problems and decline in cognitive state in older adults: a systematic review and meta-analysis.Psychological medicine · 2019Pooled it
- A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.The Journal of clinical endocrinology and metabolism · 2018Pooled it
- APOE4, Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults.JAMA network open · 2025Article
- Substance use moderates relationships between apolipoprotein E genotype, hepatitis C, cognition, and depression in Miami Adult Studies on HIV (MASH) participants.Journal of neurovirology · 2024Article
- Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning.International journal of geriatric psychiatry · 2023Article
- Effect of interactions betweenArchives of medical science : AMS · 2021Article
- Trajectories of neuropsychiatric symptoms over time in healthy volunteers and risk of MCI and dementia.International journal of geriatric psychiatry · 2019Article
- Aging Audiences: Association of Live Performance Attendance and Cognitive Decline in a Biracial Sample.Journal of aging and health · 2018Article
- Putative mechanisms of cognitive decline with implications for clinical research and practice.Nursing forum · 2018Article
- Article
- Racial Differences in the Association Between Apolipoprotein E Risk Alleles and Overall and Total Cardiovascular Mortality Over 18 Years.Journal of the American Geriatrics Society · 2017Article
- APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.Brain imaging and behavior · 2017Article
- Apolipoprotein E polymorphisms increase the risk of post-stroke depression.Neural regeneration research · 2016Article
- Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice.Molecular neurodegeneration · 2016Article
- Depression associated with dementia.Zeitschrift fur Gerontologie und Geriatrie · 2015Review
- Role of APOE ε4 Allele and Incident Stroke on Cognitive Decline and Mortality.Alzheimer disease and associated disordersArticle
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
objectiveDepressive symptoms and the apolipoprotein E (APOE) ε4 allele are independent risk factors for cognitive decline. However, it is not clear whether the presence of both depressive symptoms and the APOE ε4 allele increases cognitive decline.
methodsA prospective study of a population-based sample of 4150 (70% African American and 63% women) participants 65 years and older who were interviewed at 3-year intervals was conducted. Depressive symptoms were measured using the 10-item version of the Center for Epidemiologic Studies Depression scale, with each item coded as presence or absence of a symptom. The APOE genotype was ascertained by DNA samples collected during follow-up. Cognitive function was assessed at the initial and follow-up interviews (average follow-up of 9.2 years), using a standardized global cognitive score.
resultsThere were 1405 (34%) participants with one or more copies of the APOE ε4 allele. In participants with no depressive symptoms, cognitive function decreased by 0.0412 unit per year among those with no copies and 0.0704 unit per year among those with one or more copies of the APOE ε4 allele. For each additional symptom of depression, cognitive decline increased by 0.0021 unit per year among those with no copies and 0.0051 unit per year among those with one or more copies of the APOE ε4 allele. The three-way interaction of depressive symptoms, APOE ε4 allele, and time was significant (p = .021).
conclusionsThe association of depressive symptoms on cognitive decline was increased among participants with one or more copies of the APOE ε4 allele compared with those without the allele.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.