ArticleLearning & memory (Cold Spring Harbor, N.Y.)2014
A novel role for the rat retrosplenial cortex in cognitive control.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Alterations in the topological organization of the default-mode network in Tourette syndrome.BMC neurology · 2023Article
- Identification of the Neural Correlates Underlying Conflict Resolution Performance Using a Rodent Analogue of the Stroop Tests.Neuroscience · 2023Article
- Article
- The anterior thalamic nuclei and cognition: A role beyond space?Neuroscience and biobehavioral reviews · 2021Review
- Calretinin and calbindin architecture of the midline thalamus associated with prefrontal-hippocampal circuitry.Hippocampus · 2021Article
- In vivo imaging of immediate early gene expression dynamics segregates neuronal ensemble of memories of dual events.Molecular brain · 2021Article
- Retrosplenial Cortical Connectivity with Frontal Basal Ganglia Networks.Journal of cognitive neuroscience · 2021Article
- Dual-Factor Representation of the Environmental Context in the Retrosplenial Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Intact Behavioral Expression of Contextual Fear, Context Discrimination, and Object Discrimination Memories Acquired in the Absence of the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Peering into the Brain through the Retrosplenial Cortex to Assess Cognitive Function of the Injured Brain.Neurotrauma reports · 2021Article
- Retrosplenial cortex damage impairs unimodal sensory preconditioning.Behavioral neuroscience · 2020Article
- Retrosplenial cortex and its role in cue-specific learning and memory.Neuroscience and biobehavioral reviews · 2019Review
- Permanent damage or temporary silencing of retrosplenial cortex impairs the expression of a negative patterning discrimination.Neurobiology of learning and memory · 2019Article
- The impact of fasting on resting state brain networks in mice.Scientific reports · 2019Article
- Do the rat anterior thalamic nuclei contribute to behavioural flexibility?Behavioural brain research · 2019Article
- Anterior thalamic nuclei, but not retrosplenial cortex, lesions abolish latent inhibition in rats.Behavioral neuroscience · 2018Article
- The retrosplenial cortical role in encoding behaviorally significant cues.Behavioral neuroscience · 2018Review
- When is the rat retrosplenial cortex required for stimulus integration?Behavioral neuroscience · 2018Article
- The rat retrosplenial cortex as a link for frontal functions: A lesion analysis.Behavioural brain research · 2017Article
- Retrosplenial Cortical Neurons Encode Navigational Cues, Trajectories and Reward Locations During Goal Directed Navigation.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
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5 authors.
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Abstract
By virtue of its frontal and hippocampal connections, the retrosplenial cortex is uniquely placed to support cognition. Here, we tested whether the retrosplenial cortex is required for frontal tasks analogous to the Stroop Test, i.e., for the ability to select between conflicting responses and inhibit responding to task-irrelevant cues. Rats first acquired two instrumental conditional discriminations, one auditory and one visual, set in two distinct contexts. As a result, rats were rewarded for pressing either the right or left lever when a particular auditory or visual signal was present. In extinction, rats received compound stimuli that either comprised the auditory and visual elements that signaled the same lever response (congruent) or signaled different lever responses (incongruent) during training. On conflict (incongruent) trials, lever selection by sham-operated animals followed the stimulus element that had previously been trained in that same test context, whereas animals with retrosplenial cortex lesions failed to disambiguate the conflicting response cues. Subsequent experiments demonstrated that this abnormality on conflict trials was not due to a failure in distinguishing the contexts. Rather, these data reveal the selective involvement of the rat retrosplenial cortex in response conflict, and so extend the frontal system underlying cognitive control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.