ArticleClinical immunology (Orlando, Fla.)2014
A T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus.
Article in Clinical immunology (Orlando, Fla.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Identification of Genetic Diagnostic Markers for Systemic Lupus Erythematosus.Genetics research · 2026Article
- The Impact of the IL-10 Gene Polymorphism on mRNA Expression and IL-10 Serum Concentration in Polish Lupus Patients.International journal of molecular sciences · 2024Article
- Cuproptosis-related gene identification and immune infiltration analysis in systemic lupus erythematosus.Frontiers in immunology · 2023Article
- AlteredDiagnostics (Basel, Switzerland) · 2022Article
- Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice.International journal of molecular sciences · 2021Article
- Article
- MALAT1 is involved in type I IFNs-mediated systemic lupus erythematosus by up-regulating OAS2, OAS3, and OASL.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Integrated analysis of lncRNA, miRNA and mRNA expression profiling in patients with systemic lupus erythematosus.Archives of medical science : AMS · 2019Article
- Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.Frontiers in immunology · 2019Article
- De novo pathway-based biomarker identification.Nucleic acids research · 2017Article
- BLK pathway-associated rs13277113 GA genotype is more frequent in SLE patients and associated with low gene expression and increased flares.Clinical rheumatology · 2017Article
- New insights into the immunopathogenesis of systemic lupus erythematosus.Nature reviews. Rheumatology · 2016Review
- Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.The Journal of clinical investigation · 2016Article
- The effects of storage temperature on PBMC gene expression.BMC immunology · 2016Article
- Common Marker Genes Identified from Various Sample Types for Systemic Lupus Erythematosus.PloS one · 2016Article
- Association of interleukin-10 promoter haplotypes with disease susceptibility and IL-10 levels in Mexican patients with systemic lupus erythematosus.Clinical and experimental medicine · 2015Article
- Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus.Clinical immunology (Orlando, Fla.) · 2015Article
- T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity.The Journal of clinical investigation · 2015Review
- Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN.BMC genomics · 2015Article
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Systemic Lupus Erythematosus (SLE) remains a challenging disease to diagnose and follow, as no reliable biomarkers are known to date. We designed a gene expression panel with 40 genes known to play a role in SLE pathogenesis. We found that the combined expression of these genes in SLE T cells can accurately differentiate SLE from healthy individuals and patients with other autoimmune diseases. The accuracy of the test increased further (83%) when only three out of the initial genes (OAS2, CD70 and IL10) were used. A T cell score, calculated from the combined expression levels of these genes, correlated positively with various SLE activity markers in a cross-sectional cohort and in a few patients that were followed prospectively. These data showcase the usefulness of measuring mRNA levels of key molecules in diagnosing and following patients with SLE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.