Evidence map›Paper›PMID 24434161›Full record

ArticlePreventive medicine2014

Association of depressive symptoms, trait anxiety, and perceived stress with subclinical atherosclerosis: results from the Chicago Healthy Aging Study (CHAS).

Rosalba Hernandez, Norrina Bai Allen, Kiang Liu, Jeremiah Stamler, Kathryn Jean Reid, Phyllis C Zee, Donghong Wu, Joseph Kang, Daniel B Garside, Martha L Daviglus

Abstract readComparative Study
In one paragraph

Article in Preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rosalba HernandezDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: rosalba.hernandez@northwestern.edu.
Norrina Bai AllenDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kiang LiuDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jeremiah StamlerDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kathryn Jean ReidKen and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Phyllis C ZeeKen and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Chicago, IL, USA.
Donghong WuDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Joseph KangDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Daniel B GarsideDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.
Martha L DaviglusDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.

Funding

RESEARCH TRAINING IN CVD EPIDEMIOLOGY AND PREVENTIONT32HL069771 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Mercedes Renee Carnethon · 2003 to 2026
$5.9M
Sleep and Cardiovascular HealthR01HL090873 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ZEE, PHYLLIS C. · 2009 to 2012
$2.0M
Chicago Healthy Aging Low Risk MRI Angiography (CHARISMA) StudyR01HL089695 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARR, JAMES, LLOYD-JONES, DONALD M · 2009 to 2012
$1.8M
NHLBI NIH HHS R01 HL089695NHLBI NIH HHS R01 HL090873NHLBI NIH HHS T32 HL069771NHLBI NIH HHS T32HL 069771-10PHS HHS R01HLO89695
6 · The paper itself

Abstract

objectiveExamine the association between multiple psychological factors (depressive symptoms, trait anxiety, perceived stress) and subclinical atherosclerosis in older age.

methodThis cross-sectional study included 1101 adults ages 65-84 from the Chicago Healthy Aging Study (CHAS - 2007-2010). Previously validated self-report instruments were used to assess psychological factors. Non-invasive methods were used to assess subclinical atherosclerosis in two regions of the body, i.e., ankle-brachial blood pressure index (ABI) and coronary artery calcification (CAC). Multivariate logistic regression was used to examine the association between each psychological measure and subclinical atherosclerosis, after the adjustment for socio-demographic factors, sleep quality, young adulthood/early middle age and late-life CVD risk status, and psychological ill-being as appropriate.

resultsThe burden of major cardiovascular disease risk factors did not significantly differ across tertiles of psychological factors. In multivariate adjusted models, trait anxiety was associated with calcification: those in the second tertile were significantly more likely to have CAC >0 compared to those in the lowest anxiety tertile [OR=1.68; 95% CI=1.09-2.58], but no significant difference was observed for Tertile III of trait anxiety [OR=1.31; 95% CI=0.75-2.27]. No association was seen between psychological measures and ABI.

conclusionOf several psychological factors, only trait anxiety was significantly associated with CAC.

Indexed as

AgedAgingAnkle Brachial IndexAnxietyAtherosclerosisCardiovascular DiseasesChicagoCohort StudiesCross-Sectional StudiesDepressionFemaleHumansLogistic ModelsMalePrevalenceSelf ReportAnkle brachial indexCardiovascular riskCoronary artery calcificationOlder adultsPopulation studyPsychological factorsSubclinical atherosclerosis

Identifiers

PMID24434161
PMCPMC4153417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.