ArticleThe journal of sexual medicine2014
Uric acid level and erectile dysfunction in patients with coronary artery disease.
Article in The journal of sexual medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The Association of Erectile Dysfunction and Cardiovascular Disease: A Systematic Critical Review.American journal of men's health · 2017Pooled it
- Association between Gout and Erectile Dysfunction: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- The association between uric acid and erectile dysfunction in US adults: NHANES 2001-2004.BMC nephrology · 2024Article
- Insights into modifiable risk factors of erectile dysfunction, a wide-angled Mendelian Randomization study.Journal of advanced research · 2024Article
- Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction.Sexual medicine · 2021Article
- Stage effect of chronic kidney disease in erectile function.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
introductionErectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD).
aimThis study aims to evaluate the association of serum uric acid levels with presence and severity of ED in patients presenting with chest pain of presumed cardiac origin.
methodsThis is a cross-sectional study of 312 adult male patients with suspected CAD who underwent exercise stress test (EST) for workup of chest pain and completed a sexual health inventory for men survey form to determine the presence and severity of ED. Routine serum biochemistry (and uric acid levels) were measured. Logistic regression analysis was used to assess risk factors for ED.
main outcome measuresThe short version of the International Index of Erectile Function questionnaire diagnosed ED (cutoff score ≤ 21). Serum uric acid levels were determined. Patients with chest pain of suspected cardiac origin underwent an EST.
resultsOne hundred forty-nine of 312 (47.7%) male subjects had ED by survey criteria. Patients with ED were older and had more frequent CAD, hypertension, diabetes and impaired renal function, and also had significantly higher levels of uric acid, fibrinogen, glucose, C-reactive protein, triglycerides compared with patients without ED. Uric acid levels were associated with ED by univariate analysis (odds ratio = 1.36, P = 0.002); however, this association was not observed in multivariate analysis adjusted for estimated glomerular filtration rate.
conclusionSubjects presenting with chest pain of presumed cardiac origin are more likely to have ED if they have elevated uric acid levels.
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