ArticleArthritis research & therapy2014
Diagnostic accuracy of blood B-cell subset profiling and autoimmunity markers in Sjögren's syndrome.
Article in Arthritis research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Clinical characteristics and risk factors of Helicobacter pylori infection-associated Sjogren's syndrome.Immunity, inflammation and disease · 2023Observational
- Added value of lymphocyte subpopulations in the classification of Sjögren's syndrome.Scientific reports · 2023Article
- Comparison of the deep immune profiling of B cell subsets between healthy adults and Sjögren's syndrome.Annals of medicine · 2022Article
- Impression Cytology andFrontiers in immunology · 2022Article
- The Imbalance of Circulating Follicular T Helper Cell Subsets in Primary Sjögren's Syndrome Associates With Serological Alterations and Abnormal B-Cell Distribution.Frontiers in immunology · 2021Article
- Usefulness of rheumatoid factor as an immunological and prognostic marker in PSS patients.Clinical rheumatology · 2019Article
- Clinical features and potential relevant factors of renal involvement in primary Sjögren's syndrome.International journal of rheumatic diseases · 2019Article
- Association between memory B-cells and clinical and immunological features of primary Sjögren's syndrome and Sicca patients.Rheumatology international · 2018Article
- Comparison of 2002 AECG and 2016 ACR/EULAR classification criteria and added value of salivary gland ultrasonography in a patient cohort with suspected primary Sjögren's syndrome.Arthritis research & therapy · 2017Article
- Memory B Cells and Response to Abatacept in Rheumatoid Arthritis.Clinical reviews in allergy & immunology · 2017Article
- Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?Clinical reviews in allergy & immunology · 2017Review
- Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up.Clinical reviews in allergy & immunology · 2017Review
- The Differential Diagnosis of Dry Eyes, Dry Mouth, and Parotidomegaly: A Comprehensive Review.Clinical reviews in allergy & immunology · 2015Review
- Polychromatic flow cytometry in evaluating rheumatic disease patients.Arthritis research & therapy · 2015Review
- Sjögren's syndrome: still not fully understood disease.Rheumatology international · 2015Review
- An in silico Approach Reveals Associations between Genetic and Epigenetic Factors within Regulatory Elements in B Cells from Primary Sjögren's Syndrome Patients.Frontiers in immunology · 2015Article
- Level of agreement between 2002 American-European Consensus Group and 2012 American College of Rheumatology classification criteria for Sjögren's syndrome and reasons for discrepancies.Arthritis research & therapy · 2014Article
- The epidemiology of Sjögren's syndrome.Clinical epidemiology · 2014Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aims of this study were to evaluate the diagnostic accuracy of blood B-cell subset profiling and immune-system activation marker assays in primary Sjögren's syndrome (pSS) and to assess whether adding these tools to the current laboratory item would improve the American-European Consensus Group (AECG) criteria.
methodsIn a single-center cohort of patients with suspected pSS, we tested the diagnostic performance of anti-SSA, antinuclear antibody (ANA), rheumatoid factor (RF), gammaglobulins, IgG titers, and B-cell ratio defined as (Bm2 + Bm2')/(eBm5 + Bm5), determined using flow cytometry. The reference standard was a clinical diagnosis of pSS established by a panel of experts.
resultsOf 181 patients included in the study, 77 had pSS. By logistic regression analysis, only ANA ≥1:640 (sensitivity, 70.4%; specificity 83.2%) and B-cell ratio ≥5 (sensitivity, 52.1%; specificity, 83.2%) showed independent associations with pSS of similar strength. In anti-SSA-negative patients, presence of either of these two criteria had 71.0% sensitivity but only 67.3% specificity for pSS; whereas combining both criteria had 96.2% specificity but only 12.9% sensitivity. Adding either of these two criteria to the AECG criteria set increased sensitivity from 83.1% to 90.9% but decreased specificity from 97.1% to 85.6%, whereas adding both criteria in combination did not substantially modify the diagnostic performance of the criteria set. The adjunction of RF + ANA ≥1:320, as proposed in the new American College of Rheumatology (ACR) criteria, did not improve the diagnostic value of anti-SSA.
conclusionsBlood B-cell subset profiling is a simple test that has good diagnostic properties for pSS. However, adding this test, with or without ANA positivity, does not improve current classification criteria.
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