Evidence map›Paper›PMID 24433146›Full record

ReviewExpert review of proteomics2014

Metalloproteomics: challenges and prospective for clinical research applications.

Dax Fu, Lydia Finney

Abstract readReview
In one paragraph

Review in Expert review of proteomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Pull-Down of Metalloproteins in Their Native States by Using Desthiobiotin-Based Probes.Chembiochem : a European journal of chemical biology · 2019
    Article
  4. Article
  5. In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dax FuDepartment of Physiology, Johns Hopkins School of Medicine, 202 Physiology Building, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Lydia Finney
Argonne National Laboratory · US

Funding

Structure and Mechanism of Zinc Efflux TransportersR01GM065137 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FU, DAX · 2002 to 2018
$5.6M
NIGMS NIH HHS R01 GM065137
6 · The paper itself

Abstract

Metals are essential cofactors, utilized in many critical cellular processes. For example, zinc is important in insulin biosynthesis and may play a role in Alzheimer's disease, but much of how the zinc-mediated process remains unknown. Knowing which metal is in which protein at a given point in time would lead to new insights into how metals work in biological systems. New tools are being developed to investigate the biochemistry and cell biology of metals, with potential for biomedical applications. In this report, we consider the promise and limitations of metalloproteins detection techniques. We provide a brief overview of the techniques available and a discussion of the technical challenges to biomedical applications, with particular focus on what must be overcome for the potential of these approaches to be achieved.

Indexed as

Biomedical ResearchCoordination ComplexesHumansMetalloproteinsProteomeProteomicsZincCoordination ComplexesMetalloproteinsProteomeZinc

Identifiers

PMID24433146
PMCPMC4598182
OpenAlexW2114789768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.