ArticleACS nano2014
Gold nanowire based electrical DNA detection using rolling circle amplification.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Design and Optimization of Isothermal Gene Amplification for Generation of High-Gain Oligonucleotide Products by MicroRNAs.ACS measurement science au · 2024Article
- Development of a Gold Nanoparticle-Based Sensor for Authentication of Organic Milk Based on Differential Levels of miRNA.Nanomaterials (Basel, Switzerland) · 2024Article
- Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization.ACS nano · 2023Article
- Recent advances and challenges of biosensing in point-of-care molecular diagnosis.Sensors and actuators. B, Chemical · 2021Review
- Rolling Circle Amplification in Integrated Microsystems: An Uncut Gem toward Massively Multiplexed Pathogen Diagnostics and Genotyping.Accounts of chemical research · 2021Review
- Electrochemical Genosensing ofSensors (Basel, Switzerland) · 2021Article
- Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections.Nanomaterials (Basel, Switzerland) · 2021Review
- Visual detection of microRNA146a by using RNA-functionalized gold nanoparticles.Mikrochimica acta · 2020Article
- Rolling circle amplification based colorimetric determination of Staphylococcus aureus.Mikrochimica acta · 2020Article
- Hybrid gold/DNA nanowire circuit with sub-10 nm nanostructure arrays.Microsystems & nanoengineering · 2020Article
- Highly sensitive and specific screening of EGFR mutation using a PNA microarray-based fluorometric assay based on rolling circle amplification and graphene oxide.RSC advances · 2019Article
- Graphene oxide and enzyme-assisted dual-cycling amplification method for sensitive fluorometric determination of DNA.Mikrochimica acta · 2019Article
- Construction and characterization of metal ion-containing DNA nanowires for synthetic biology and nanotechnology.Scientific reports · 2019Article
- Review of the Electrical Characterization of Metallic Nanowires on DNA Templates.International journal of molecular sciences · 2018Review
- Ultrasensitive optical biosensor for detection of miRNA-155 using positively charged Au nanoparticles.Scientific reports · 2018Article
- Advanced DNA-Based Point-of-Care Diagnostic Methods for Plant Diseases Detection.Frontiers in plant science · 2017Review
- Sensitive detection of miRNA by using hybridization chain reaction coupled with positively charged gold nanoparticles.Scientific reports · 2016Article
- Recent Progresses in Nanobiosensing for Food Safety Analysis.Sensors (Basel, Switzerland) · 2016Review
- Mechanically Induced Catalytic Amplification Reaction for Readout of Receptor-Mediated Cellular Forces.Angewandte Chemie (International ed. in English) · 2016Article
- Gold Nanoparticles for In Vitro Diagnostics.Chemical reviews · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present an electrical sensor that uses rolling circle amplification (RCA) of DNA to stretch across the gap between two electrodes, interact with metal nanoparticle seeds to generate an electrically conductive nanowire, and produce electrical signals upon detection of specific target DNA sequences. RCA is a highly specific molecular detection mechanism based on DNA probe circularization. With this technique, long single-stranded DNA with simple repetitive sequences are produced. Here we show that stretched RCA products can be metalized using silver or gold solutions to form metal wires. Upon metallization, the resistance drops from TΩ to kΩ for silver and to Ω for gold. Metallization is seeded by gold nanoparticles aligned along the single-stranded DNA product through hybridization of functionalized oligonucleotides. We show that combining RCA with electrical DNA detection produces results in readout with very high signal-to-noise ratio, an essential feature for sensitive and specific detection assays. Finally, we demonstrate detection of 10 ng of Escherichia coli genomic DNA using the sensor concept.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.