ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2014
Coexisting chronic conditions associated with mortality and morbidity in adult patients with asthma.
Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Strength of association between comorbidities and asthma: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Discerning asthma endotypes through comorbidity mapping.Nature communications · 2022Pooled it
- Effects of Comorbidities on Asthma Hospitalization and Mortality Rates: A Systematic Review.Canadian respiratory journal · 2018Pooled it
- Association between allergic conditions and risk of prostate cancer: A Prisma-Compliant Systematic Review and Meta-Analysis.Scientific reports · 2016Pooled it
- The association between asthma and heart failure - a systematic review and meta-analysis.European clinical respiratory journal · 2026Review
- Development, validation, and visualization of a machine learning-based predictive model for depression risk in sleep disorder patients.BMC psychiatry · 2025Article
- Association between mental health disorders and asthma exacerbations in adults: a retrospective cohort study in UK primary care.BMJ open respiratory research · 2025Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Impact of COVID-19 pandemic on sex disparities in asthma healthcare utilisation and outcomes: a population study.ERJ open research · 2025Article
- Association between pediatric asthma and adult polycystic ovarian syndrome (PCOS): a cross-sectional analysis of the UAE healthy future Study (UAEHFS).Frontiers in endocrinology · 2023Article
- Article
- Association Between Self-Reported Polycystic Ovary Syndrome with Chronic Diseases Among Emiratis: A Cross-Sectional Analysis from the UAE Healthy Future Study.International journal of women's health · 2023Article
- The effect and relative importance of sleep disorders for all-cause mortality in middle-aged and older asthmatics.BMC geriatrics · 2022Article
- Demographic, lifestyle and comorbid risk factors for all-cause mortality in a Danish cohort of middle-aged adults with incident asthma.BMJ open · 2021Article
- Prodromal clinical, demographic, and socio-ecological correlates of asthma in adults: a 10-year statewide big data multi-domain analysis.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Article
- Age- and sex-specific prevalence of chronic comorbidity in adult patients with asthma: A real-life study.NPJ primary care respiratory medicine · 2019Article
- Association between Rheumatoid Arthritis and Respiratory Allergic Diseases in Korean Adults: A Propensity Score Matched Case-Control Study.International journal of rheumatology · 2018Article
- Alcohol and the Lung.Alcohol research : current reviews · 2017Review
- The impact of comorbidities on productivity loss in asthma patients.Respiratory research · 2016Article
- Disparities in Mortality and Morbidity in Pediatric Asthma Hospitalizations, 2007 to 2011.Academic pediatrics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveMany asthma patients suffer from chronic conditions other than asthma. We investigated the specific contribution of common comorbidities on mortality and morbidity in adult asthma.
methodsIn an observational study of adults with incident asthma identified between 1999 and 2003 using National Veterans Affairs and Centers for Medicare and Medicaid Services encounter databases (n = 25 975, follow-up 3.0 ± 1.7 years), association between 13 most prevalent comorbidities (hypertension, ischemic heart disease (IHD), osteoarthritis, rheumatoid arthritis, diabetes, mental disorders, substance/drug abuse, enlarged prostate, depression, cancer, alcoholism, HIV and heart failure) and four conditions previously associated with asthma (sleep apnea, gastroesophageal reflux disease (GERD), rhinitis and sinusitis) and mortality, hospitalizations and asthma exacerbations were assessed using multivariate regression analyses adjusted for other clinically important covariates.
resultsHIV followed by alcoholism and mental disorders among 18-45-years old, and heart failure, diabetes, IHD and cancer among those ≥ 65 years old were associated with an increased risk of all-cause mortality. Many conditions were associated with increased risk for all-cause hospitalizations, but the increased risk was consistent across all ages for mental disorders. For asthma exacerbations, mental disorder followed by substance abuse and IHD were associated with increased risk among those 18-45 years old, and chronic sinusitis, mental disorder and IHD among those ≥ 65-years old. GERD was associated with decreased risk for asthma exacerbation in all ages.
conclusionsMany comorbidities are associated with poor outcome in adult asthmatics and their effect differs by age. Mental disorders are associated with increased risk of mortality and morbidity across ages.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.