Evidence map›Paper›PMID 24432858›Full record

ArticleAmerican journal on intellectual and developmental disabilities2013

Biobehavioral indicators of social fear in young children with fragile X syndrome.

Bridgette L Tonnsen, Svetlana V Shinkareva, Sara C Deal, Deborah D Hatton, Jane E Roberts

Abstract read
In one paragraph

Article in American journal on intellectual and developmental disabilities, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Autonomic Function in Fragile X Syndrome: A Systematic Review.Journal of intellectual disability research : JIDR · 2026
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Attention Bias and Prodromal Anxiety Symptoms in Toddlers With Fragile X Syndrome and Down Syndrome.American journal on intellectual and developmental disabilities · 2021
    Article
  8. Article
  9. Article
  10. Anxiety and threat-related attentional biases in adolescents with fragile X syndrome.Journal of intellectual disability research : JIDR · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Maternal predictors of anxiety risk in young males with fragile X.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bridgette L Tonnsen
Svetlana V Shinkareva
Sara C Deal
Deborah D Hatton
Jane E Roberts

Funding

UNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIVEN, JOSEPH · 1985 to 2012
$28.7M
Supplement to The Emergence and Stability of Autism in Fragile X SyndromeR01MH090194 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ROBERTS, JANE E · 2011 to 2020
$5.4M
Predicting Autism through Behavioral and Biomarkers of Attention in InfantsF31MH095318 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KELLEHER, BRIDGETTE LYNNE · 2011 to 2014
$97k
NICHD NIH HHS P30 HD003110NICHD NIH HHS P30-HD003110-35S1NIMH NIH HHS F31 MH095318NIMH NIH HHS F31-MH095318-01A01NIMH NIH HHS R01 MH090194NIMH NIH HHS R01-MH090194-01A1
6 · The paper itself

Abstract

Anxiety is among the most impairing conditions associated with Fragile X syndrome (FXS) and is putatively linked to atypical physiological arousal. However, few studies have examined this association in young children with FXS. The authors examined whether patterns of arousal and behavior during an experimental stranger approach paradigm differ between a cross-sectional sample of 21 young children with FXS and 19 controls (12-58 months old). Groups did not differ in mean levels of behavioral fear. Unlike the control group, however, the FXS group demonstrated increased facial fear at older ages, as well as age-dependent changes in associations between heart activity and distress vocalizations. These findings may inform theoretical models of anxiety etiology in FXS and early detection efforts.

Indexed as

ArousalChild, PreschoolCross-Sectional StudiesFragile X SyndromeHeart RateHumansInfantMalePhobic Disorders

Identifiers

PMID24432858
PMCPMC4283795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.