ArticlePhysiology & behavior2014
Depressive symptoms are associated with allostatic load among community-dwelling older adults.
Article in Physiology & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity.International journal of environmental research and public health · 2023Pooled it
- Physiological responses to acute psychological stress as a biomarker for depression: A systematic review and meta-analysis.Psychological bulletinPooled it
- Depression, but not anxiety, is associated with epigenetic age accelerations among Asian older adults.Molecular psychiatry · 2026Article
- The relationship between allostatic load levels and time to deterioration of health-related quality of life in non-small cell lung cancer patients.Journal of cancer survivorship : research and practice · 2026Article
- Allostatic load profiles, resilience, and psychosocial adaptation in young adults.Frontiers in psychology · 2026Article
- Chronic Physiological Dysregulation and Changes in Depressive Symptoms: Testing Sex and Race as Vulnerability Factors.Journal of racial and ethnic health disparities · 2025Article
- The influence of negative wealth shock on depressive symptoms and major depressive episode among older adults.SSM - population health · 2025Article
- Integrative DNA methylation and transcriptome analysis reveal cell-type specific patterns in response to elevated allostatic load.Epigenetics · 2025Article
- Integrating allostasis and emerging technologies to study complex diseases.Communications biology · 2025Review
- Stress-related multisystem dysregulation during adolescence predicts mental health symptoms in young adulthood.Psychological medicine · 2025Article
- Exploring the relationship between depressive symptoms, allostatic load, and income inequality in US adults aged 20 and older.Social science & medicine (1982) · 2025Article
- Five hypothesized biological mechanisms linking adverse childhood experiences with anxiety, depression, and PTSD: A scoping review.Neuroscience and biobehavioral reviews · 2025Article
- The role of allostatic load in adverse pregnancy outcomes: a multisystem, developmental perspective.Frontiers in global women's health · 2025Review
- The Interplay between Structural Inequality, Allostatic Load, Inflammation, and Cancer in Black Americans: A Narrative Review.Cancers · 2024Review
- Race by Sex Intersectional Differences in the Association between Allostatic Load and Depression in US Adults: 2005-2018.Global journal of epidemiology and infectious disease · 2024Article
- Continuous Exposure to Terrorism during the COVID-19 Pandemic: A Moderated Mediation Model in the Israeli Context.International journal of environmental research and public health · 2023Article
- A predictive coding framework of allostatic-interoceptive overload in frontotemporal dementia.Trends in neurosciences · 2022Review
- Depressive symptoms and allostatic load have a bidirectional association among Puerto Rican older adults.Psychological medicine · 2022Article
- Association of Allostatic Load With Overall Mortality Among Patients With Metastatic Non-Small Cell Lung Cancer.JAMA network open · 2022Observational
- Previous functional social and behavioral rhythms affect resilience to COVID-19-related stress among old adults.Journal of public health research · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The allostatic load model has been used to quantify the physiological costs of the body's response to repeated stressful demands and may provide a useful, integrative perspective on the various correlates of late-life depressive symptoms. We interviewed 125 Rochester, NY adults, ranging in age from 67 to 94 years. We employed an allostatic load score as a measure of multisystem dysfunction in hypothalamic–pituitary–adrenal axis function, immune function, anabolic activity, and cardiovascular activity. Overall, affective, and somatic depressive symptom scores were computed using the 20-item Center for Epidemiologic Studies Depression Scale. Multiple linear regression models were used to estimate associations between allostatic load scores and affective, somatic, and overall depressive symptoms. Among our sample of mean age 76.1 years, the one-week prevalence of clinically significant depressive symptoms was 12.8%. In models adjusting for demographic, socioeconomic, and health-related factors, higher allostatic load scores were associated with elevated scores for overall, affective, and somatic depressive symptoms: beta = 1.21 (95% CI = 0.38, 2.05); beta = 0.14 (95% CI = 0.040, 0.24); beta = 0.60 (95% CI = 0.23, 0.97), respectively. Our results suggest that allostatic load measure is associated with late-life depressive symptoms. This association appears to be of clinical significance, as the magnitude of the effect size was comparable (but opposite in direction) to that of antidepressant use. Future research should examine the inter-relationships of allostatic load, psychological stress, and late-life depressive symptoms.
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