ArticleAnnals of translational medicine2013
Effect of high fat-diet and obesity on gastrointestinal motility.
Article in Annals of translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03841578 (Effects of Dark Chocolate on Gastrointestinal Motility in Healthy Subjects), which is not on this map. Cited by 68 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Dark Chocolate on Gastrointestinal Motility in Healthy Subjects
Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Pooled it
- Pooled it
- Pooled it
- Obesity and Risk of Small Intestine Bacterial Overgrowth: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2020Pooled it
- A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time.The AAPS journal · 2016Pooled it
- Dietary Intake and Symptom Severity in Women with Fecal Incontinence.International urogynecology journal · 2024Trial
- Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota.Biomedical chromatography : BMC · 2017Trial
- Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk.Immunity, inflammation and disease · 2026Review
- Associations between five anthropometric indices and fecal incontinence: A cross-sectional study based on the 2005 to 2010 NHANES data.Medicine · 2026Article
- High Prevalence and Low Incidence of Constipation Among Glucagon-Like Peptide-1 Receptor Agonist Users.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Review
- Article
- Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet.Molecular neurobiology · 2025Article
- Targeting the Gut Microbiota's Role in Host Energy Absorption With Precision Nutrition Interventions for the Prevention and Treatment of Obesity.Nutrition reviews · 2025Review
- Differences in Gastrointestinal Motility in Adults with Type 1 and Type 2 Diabetes Using Wireless Motility Capsule.Digestive diseases and sciences · 2025Article
- Association of Genetically Predicted Obesity and Stool Frequency: Evidence From an Observational and Mendelian Randomization Study.Journal of neurogastroenterology and motility · 2025Article
- Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats.Autonomic neuroscience : basic & clinical · 2024Article
- Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Related Diseases-Current State of Knowledge.Biomedicines · 2024Review
- Effect of Body Weight and Obesity on Esophageal Function.Physiological research · 2023Article
- Impaired colonic motility in high-glycemic diet-induced diabetic mice is associated with disrupted gut microbiota and neuromuscular function.Endocrine connections · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is highly prevalent worldwide and is associated with significant morbidity and mortality. The focus of this review is to delineate the changes in gastrointestinal motility observed in obesity. A systematic review of the published literature on obesity and gastrointestinal motility was performed. Here, we describe the current understanding of the changes in obesity in the esophagus, stomach, small intestine and colon. Major findings include supportive evidence for increased gastroesophageal reflux disease and esophageal motility disorders in obesity, and a rapid gastric emptying time seen in obese individuals. The proximal small intestinal transit seems to be increased in obesity and this may be secondary to efficient nutrient absorption and subsequent lack of nutrient-induced satiety signals conveyed from the small intestine. In obesity, there is some evidence for delayed colonic transit as well as a reduction in colonic serotonin availability. The molecular mechanisms underlying altered motility in obesity could be secondary to reduced cannabinoids or its receptor cannabinoid receptor 1 (CB1) expression as well as due to loss of neuronal nitric oxide synthase (nNOS) neurons. The interactions of diet and obesity and the alteration of microbiota in this setting are just being explored and may offer novel insights into the changes of gastrointestinal motility in obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.