ReviewJournal of children's orthopaedics2013
Idiopathic scoliosis: etiological concepts and hypotheses.
Review in Journal of children's orthopaedics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Pooled it
- Association of IL-6 and MMP-3 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis: a meta-analysis.Journal of genetics · 2016Pooled it
- Lumbar and Thoracolumbar Curves Are Associated with Coronal Lower Limb Malalignment in Adolescent Idiopathic Scoliosis.Medicina (Kaunas, Lithuania) · 2026Article
- The effects of an 8-week Pilates program on physical fitness and spinal posture in adult women.Journal of exercise rehabilitation · 2026Article
- Integrating intrinsic musculoskeletal pathology and genetics: Recent advances in unravelling the causative factors of adolescent idiopathic scoliosis.Bone reports · 2025Review
- Preoperative Evaluation of Adolescent Idiopathic Scoliosis: The Relevance of Routine Magnetic Resonance Imaging.Cureus · 2025Article
- 2D and 3D Classification Systems for Adolescent Idiopathic Scoliosis: Clinical Implications and Technological Advances.Orthopaedic surgery · 2025Review
- Reliability of Sensorimotor Control Tests in Individuals with Adolescent Idiopathic Scoliosis.Muscles (Basel, Switzerland) · 2024Article
- Preliminary Investigation into the Association between Scoliosis and Hypoxia: A Retrospective Cohort Study on the Impact of Eliminating Hypoxic Factors on Scoliosis Outcomes.Children (Basel, Switzerland) · 2024Article
- "Real-Time Neuromonitoring" Increases the Safety and Non-Invasiveness and Shortens the Duration of Idiopathic Scoliosis Surgery.Journal of clinical medicine · 2024Article
- Efficacy of conservative treatment on exacerbation of adolescent idiopathic scoliosis.Journal of exercise rehabilitation · 2022Article
- Finite element analysis in brace treatment on adolescent idiopathic scoliosis.Medical & biological engineering & computing · 2022Review
- Changes in Health-Related Quality of Life (HRQOL) of a Specific Group of Adolescent Idiopathic Scoliosis (AIS) Patients Who Came Across Both Bracing and Surgery.Indian journal of orthopaedics · 2021Article
- Article
- Case Report: Kaposiform Hemangioendothelioma With Spinal Involvement.Frontiers in pediatrics · 2021Article
- Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis.Scientific reports · 2020Article
- Axial Skeletal Malformations in Genetically ModifiedComparative medicine · 2020Article
- Body Posture Defects and Body Composition in School-Age Children.Children (Basel, Switzerland) · 2020Article
- The Postural Control Indexes during Unipodal Support in Patients with Idiopathic Scoliosis.BioMed research international · 2020Article
- Acute Onset Atypical Severe Scoliosis: A Case Report.The Iowa orthopaedic journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scoliosis is diagnosed as idiopathic in 70 % of structural deformities affecting the spine in children and adolescents, probably reflecting our current misunderstanding of this disease. By definition, a structural scoliosis should be the result of some primary disorder. The goal of this article is to give a comprehensive overview of the currently proposed etiological concepts in idiopathic scoliosis regarding genetics, molecular biology, biomechanics, and neurology, with particular emphasis on adolescent idiopathic scoliosis (AIS). Despite the fact that numerous potential etiologies for idiopathic scoliosis have been formulated, the primary etiology of AIS remains unknown. Beyond etiology, identification of prognostic factors of AIS progression would probably be more relevant in our daily practice, with the hope of reducing repetitive exposure to radiation, unnecessary brace treatments, psychological implications, and costs-of-care related to follow-up in low-risk patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.