ArticleFrontiers in immunology2014
B cells modulate mucosal associated invariant T cell immune responses.
Article in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mining the multifunction of mucosal-associated invariant T cells in hematological malignancies and transplantation immunity: A promising hexagon soldier in immunomodulatory.Frontiers in immunology · 2022Pooled it
- Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.PLoS neglected tropical diseases · 2016Trial
- Antiviral and inflammatory immune signatures in anti-CD20-treated multiple sclerosis: a cross-sectional study.Journal of neurology · 2026Article
- Mucosal-Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
- Role of IFN-γ from Different Immune Cells inMicroorganisms · 2025Review
- Mucosal-associated invariant T (MAIT) cell responses inOxford open immunology · 2025Article
- Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.Communications biology · 2024Article
- Epigenetic regulation in epithelial cells and innate lymphocyte responses toFrontiers in immunology · 2024Article
- Mucosal-associated invariant T cells for cancer immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Review
- Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever.Cellular immunology · 2022Article
- Mucosal-Associated Invariant T (MAIT) cells are highly activated in duodenal tissue of humans with Vibrio cholerae O1 infection: A preliminary report.PLoS neglected tropical diseases · 2022Article
- The P5-type ATPase ATP13A1 modulates major histocompatibility complex I-related protein 1 (MR1)-mediated antigen presentation.The Journal of biological chemistry · 2022Article
- Human MAIT Cells Respond toMicroorganisms · 2022Article
- Target tumor microenvironment by innate T cells.Frontiers in immunology · 2022Review
- Use of a MAIT-Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model ofPathogens & immunity · 2022Article
- Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae.Mucosal immunology · 2021Article
- B Cells Control Mucosal-Associated Invariant T Cell Responses toFrontiers in immunology · 2021Article
- New Insights on the Early Interaction Between Typhoid and Non-typhoidFrontiers in microbiology · 2021Review
- MAIT Cells Come to the Rescue in Cancer Immunotherapy?Cancers · 2020Review
- Differential functional patterns of memory CD4Vaccine · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings show the presence in uninfected individuals of mucosal associated invariant T (MAIT) cells that mount broad spectrum immune responses against a variety of microorganisms including Mycobacterium tuberculosis and enteric bacteria such as Escherichia coli and Salmonella. Therefore, we investigated whether MAIT immune responses to intestinal bacteria might account for the background responses observed before immunization. Here we measured MAIT immune responses to commensal and enteric pathogenic bacteria in healthy individuals with no history of oral immunization with enteric bacteria. We found that MAIT cells were activated by B cells infected with various bacteria strains (commensals and pathogens from the Enterobacteriaceae family), but not by uninfected cells. These responses were restricted by the non-classical MHC-related molecule 1 (MR1) and involved the endocytic pathway. The quality of these responses (i.e., cytokine profile) was dependent on bacterial load but not on the level expression of MR1 or bacterial antigen on B cell surface, suggesting that a threshold level of MR1 expression is required to trigger MAIT activation. These results provide important insights into the role of B cells as a source of antigen-presenting cells to MAIT cells and the gut immune surveillance of commensal microbiota.
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Registered trials
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