ArticleFrontiers in behavioral neuroscience2013
Pharmacological modulation of aversive responsiveness in honey bees.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Aversive memory and extinction learning for noxious stimuli and aversive tastants in bumblebees.The Journal of experimental biology · 2026Article
- The serotonin receptor AmFrontiers in physiology · 2026Article
- Article
- Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera).Nature communications · 2025Article
- Integrated Transcriptomic and Metabolomic Insights into "I See You" (ISY) Defensive Behavior inInsects · 2025Article
- Aversive learning reduces aversive-reinforcer sensitivity in honey bees.Scientific reports · 2025Article
- Dual roles of dopaminergic pathways in olfactory learning and memory in the oriental fruit fly, Bactrocera dorsalis.Pesticide biochemistry and physiology · 2024Article
- Visual learning in tethered bees modifies flight orientation and is impaired by epinastine.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- Immunohistochemical Distribution of Serotonin Transporter (SERT) in the Optic Lobe of the Honeybee,Animals : an open access journal from MDPI · 2022Article
- The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect.iScience · 2022Article
- Visuo-Motor Feedback Modulates Neural Activities in the Medulla of the Honeybee,The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Plasticity and modulation of olfactory circuits in insects.Cell and tissue research · 2021Review
- Pheromone components affect motivation and induce persistent modulation of associative learning and memory in honey bees.Communications biology · 2020Article
- Inhibitory learning of phototaxis by honeybees in a passive-avoidance task.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Genotypic trade-off between appetitive and aversive capacities in honeybees.Scientific reports · 2019Article
- Foraging Experiences Durably Modulate Honey Bees' Sucrose Responsiveness and Antennal Lobe Biogenic Amine Levels.Scientific reports · 2019Article
- Cooperative defence operates by social modulation of biogenic amine levels in the honey bee brain.Proceedings. Biological sciences · 2018Article
- Aversive gustatory learning and perception in honey bees.Scientific reports · 2018Article
- Serotonin Mediates Depression of Aggression After Acute and Chronic Social Defeat Stress in a Model Insect.Frontiers in behavioral neuroscience · 2018Article
- Social signals and aversive learning in honey bee drones and workers.Biology open · 2017Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within a honey bee colony, individuals performing different tasks exhibit different sensitivities to noxious stimuli. Noxious-stimulus sensitivity can be quantified in harnessed bees by measuring the sting extension response (SER) to a series of increasing voltages. Biogenic amines play a crucial role in the control of insect responsiveness. Whether or not these neurotransmitters affect the central control of aversive responsiveness, and more specifically of electric-shock responsiveness, remains unknown. Here we studied the involvement of the biogenic amines octopamine, dopamine and serotonin, and of the ecdysteroid 20-hydroxyecdisone in the central control of sting responsiveness to electric shocks. We injected pharmacological antagonists of these signaling pathways into the brain of harnessed bees and determined the effect of blocking these different forms of neurotransmission on shock responsiveness. We found that both octopamine and 20-hydroxyecdisone are dispensable for shock responsiveness while dopamine and serotonin act as down-regulators of sting responsiveness. As a consequence, antagonists of these two biogenic amines induce an increase in shock responsiveness to shocks of intermediate voltage; serotonin, can also increase non-specific responsiveness. We suggest that different classes of dopaminergic neurons exist in the bee brain and we define at least two categories: an instructive class mediating aversive labeling of conditioned stimuli in associative learning, and a global gain-control class which down-regulates responsiveness upon perception of noxious stimuli. Serotonergic signaling together with down-regulating dopaminergic signaling may play an essential role in attentional processes by suppressing responses to irrelevant, non-predictive stimuli, thereby allowing efficient behavioral performances.
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