Evidence map›Paper›PMID 24431481›Full record

ArticleAdvances in space research : the official journal of the Committee on Space Research (COSPAR)2010

RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for

G Zhou, L B Smilenov, H B Lieberman, T Ludwig, E J Hall

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in space research : the official journal of the Committee on Space Research (COSPAR), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

G ZhouCenter for Radiological Research, Columbia University Medical Center, New York, NY10032, USA.
L B SmilenovCenter for Radiological Research, Columbia University Medical Center, New York, NY10032, USA.
H B LiebermanCenter for Radiological Research, Columbia University Medical Center, New York, NY10032, USA.
T LudwigInstitute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.
E J HallCenter for Radiological Research, Columbia University Medical Center, New York, NY10032, USA.
Columbia University Irving Medical Center · USChinese Academy of Sciences · CN

Funding

The MRAD9 Radioresistance GeneR01GM079107 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIEBERMAN, HOWARD B. · 2006 to 2013
$2.6M
NIGMS NIH HHS R01 GM079107
6 · The paper itself

Abstract

Loss of function of DNA repair genes has been implicated in the development of many types of cancer. In the last several years, heterozygosity leading to haploinsufficiency for proteins involved in DNA repair was shown to play a role in genomic instability and carcinogenesis after DNA damage is induced, for example by ionizing radiation. Since the effect of heterozygosity for one gene is relatively small, we hypothesize that predisposition to cancer could be a result of the additive effect of heterozygosity for two or more genes critical to pathways that control DNA damage signaling, repair or apoptosis. We investigated the role of heterozygosity for

Identifiers

PMID24431481
PMCPMC3890108
OpenAlexW2093842257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.