ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
147 citing papers in PubMed, 266 citations in OpenAlex.
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- Recruitment of specific dopamine neuron sub-circuits by opioids.Addiction neuroscience · 2025Article
- Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia.Nature communications · 2025Article
- Superior colliculus projections drive dopamine neuron activity and movement but not value.bioRxiv : the preprint server for biology · 2025Article
- Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake.Alcohol (Fayetteville, N.Y.) · 2025Review
- SMUG1 DNA glycosylase modulates reward behaviour through regulation of olfactory receptor gene expression.Nucleic acids research · 2025Article
- Neuromodulation of Dopamine D2 Receptors Alters Orbitofrontal Neuronal Activity and Reduces Risk-Prone Behavior in Male Rats with Inflammatory Pain.Molecular neurobiology · 2025Article
- Subtle behavioral alterations in the spontaneous behaviors of MPTP mouse model of Parkinson's disease.Translational psychiatry · 2025Article
- The curious case of dopaminergic prediction errors and learning associative information beyond value.Nature reviews. Neuroscience · 2025Review
- Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.Current biology : CB · 2024Article
- Substantia Nigra Dopamine Neuronal Responses to Habenular Stimulation and Foot Shock Are Altered by Lesions of the Rostromedial Tegmental Nucleus.Neuroscience · 2024Article
- A dopamine mechanism for reward maximization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.bioRxiv : the preprint server for biology · 2024Article
- Optical Intracranial Self-Stimulation (oICSS): A New Behavioral Model for Studying Drug Reward and Aversion in Rodents.International journal of molecular sciences · 2024Review
- Article
- Dopamine-independent effect of rewards on choices through hidden-state inference.Nature neuroscience · 2024Article
- Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Dopamine neurons in the ventral tegmental area (VTA) are implicated in affective functions. However, it is unclear to what extent dopamine neurons in substantia nigra pars compacta (SNc) play such roles. TH-Cre transgenic mice received adeno-associated viral vectors encoding channelrhodopsin2 (ChR2), halorhodopsin (NpHR), or control vector into the VTA or SNc, resulting in selective expression of these opsins in dopamine neurons. Mice with ChR2 learned instrumental responding to deliver photostimulation into the VTA or SNc and also sought for the compartment where they received photostimulation (i.e., operant place preference). Operant place preference scores were highly correlated with self-stimulation responses. In contrast, mice with NpHR avoided the compartment where they received photostimulation into the VTA, SNc, or dorsal striatum, whereas control mice did not. These observations suggest that the excitation and inhibition of SNc dopamine neurons elicit positive and negative affective effects, respectively, similar to those of VTA dopamine neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.