ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.PLoS biology · 2023Article
- Article
- Regulation of UNC-40/DCC and UNC-6/Netrin by DAF-16 promotes functional rewiring of the injured axon.Development (Cambridge, England) · 2021Article
- PDK1 is a negative regulator of axon regeneration.Molecular brain · 2021Article
- Axon Injury-Induced Autophagy Activation Is Impaired in aInternational journal of molecular sciences · 2020Article
- Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.Autophagy · 2020Article
- Article
- AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration.Cell death & disease · 2019Article
- Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration.Restorative neurology and neuroscience · 2019Review
- The Application of Omics Technologies to Study Axon Regeneration and CNS Repair.F1000Research · 2019Review
- Functional Interactions BetweenG3 (Bethesda, Md.) · 2018Article
- Article
- Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration.Frontiers in neuroscience · 2018Review
- The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Review
- Exploiting kinase polypharmacology for nerve regeneration.Neural regeneration research · 2016Article
- Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.ACS chemical biology · 2015Article
- Functional role of RNA polymerase II and P70 S6 kinase in KCl withdrawal-induced cerebellar granule neuron apoptosis.The Journal of biological chemistry · 2015Article
- The necessary role of mTORC1 in central nervous system axon regeneration.Neural regeneration research · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ability of axons to regrow after injury is determined by the complex interplay of intrinsic growth programs and external cues. In Caenorhabditis elegans mechanosensory neuron, axons exhibit robust regenerative regrowth following laser axotomy. By surveying conserved metabolic signaling pathways, we have identified the ribosomal S6 kinase RSKS-1 as a new cell-autonomous inhibitor of axon regeneration. RSKS-1 is not required for axonal development but inhibits axon regrowth after injury in multiple neuron types. Loss of function in rsks-1 results in more rapid growth cone formation after injury and accelerates subsequent axon extension. The enhanced regrowth of rsks-1 mutants is partly dependent on the DLK-1 MAPK cascade. An essential output of RSKS-1 in axon regrowth is the metabolic sensor AMP kinase, AAK-2. We further show that the antidiabetic drug phenformin, which activates AMP kinase, can promote axon regrowth. Our data reveal a new function for an S6 kinase acting through an AMP kinase in regenerative growth of injured axons.
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