ReviewWiley interdisciplinary reviews. Systems biology and medicine
Glass-like dynamics in the cell and in cellular collectives.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- Protein aggregation and biomolecular condensation in hypoxic environments (Review).International journal of molecular medicine · 2024Review
- TrajPy: empowering feature engineering for trajectory analysis across domains.Bioinformatics advances · 2024Article
- Generative models of morphogenesis in developmental biology.Seminars in cell & developmental biology · 2023Review
- Dynamical heterogeneity in active glasses is inherently different from its equilibrium behavior.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Endocytosis in the context-dependent regulation of individual and collective cell properties.Nature reviews. Molecular cell biology · 2021Review
- Why does epithelia display heterogeneity? Bridging physical and biological concepts.Biophysical reviews · 2019Article
- Is cell migration a selectable trait in the natural evolution of cancer development?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Inherency of Form and Function in Animal Development and Evolution.Frontiers in physiology · 2019Review
- Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.ACS biomaterials science & engineering · 2019Article
- Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility.APL bioengineering · 2018Article
- A random first-order transition theory for an active glass.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Endocytic reawakening of motility in jammed epithelia.Nature materials · 2017Article
- Numerical Approach to Spatial Deterministic-Stochastic Models Arising in Cell Biology.PLoS computational biology · 2016Article
- Problems in biology with many scales of length: Cell-cell adhesion and cell jamming in collective cellular migration.Experimental cell research · 2016Review
- Anomalous dynamics of intruders in a crowded environment of mobile obstacles.Nature communications · 2016Article
- Physics of active jamming during collective cellular motion in a monolayer.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Understanding lung protection.Intensive care medicine · 2015Article
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4 authors.
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Abstract
Prominent fluctuations, heterogeneity, and cooperativity dominate the dynamics of the cytoskeleton as well as the dynamics of the cellular collective. Such systems are out of equilibrium, disordered, and remain poorly understood. To explain these findings, we consider a unifying mechanistic rubric that imagines these systems as comprising phases of soft condensed matter in proximity to a glass or jamming transition, with associated transitions between solid-like versus liquid-like phases. At the scale of the cytoskeleton, data suggest that intermittent dynamics, kinetic arrest, and dynamic heterogeneity represent mesoscale features of glassy protein-protein interactions that link underlying biochemical events to integrative cellular behaviors such as crawling, contraction, and remodeling. At the scale of the multicellular collective, jamming has the potential to unify diverse biological factors that previously had been considered mostly as acting separately and independently. Although a quantitative relationship between intra- and intercellular dynamics is still lacking, glassy dynamics and jamming offer insights linking the mechanobiology of cell to human physiology and pathophysiology.
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