ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Sensory signals for nausea.Trends in neurosciences · 2025Review
- Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity.ChemistryOpen · 2025Article
- Neural pathways of nausea and roles in energy balance.Current opinion in neurobiology · 2025Review
- A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing.Nature communications · 2024Article
- Characterizing a new tool to manipulate area postrema GLP1RPhysiology & behavior · 2024Article
- Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects.Plants (Basel, Switzerland) · 2023Article
- Evaluating proxies for motion sickness in rodent.IBRO neuroscience reports · 2023Article
- Modulatory effects of phytol on the antiemetic property of domperidone, possibly through the D3 Biotech · 2023Article
- Physiological changes associated with copper sulfate-induced nausea and retching in felines.Frontiers in physiology · 2023Article
- Antiemetic effects of baclofen in a shrew model of postoperative nausea and vomiting: Whole-transcriptome analysis in the nucleus of the solitary tract.CNS neuroscience & therapeutics · 2022Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- An emerging method to noninvasively measure and identify vagal response markers to enable bioelectronic control of gastroparesis symptoms with gastric electrical stimulation.Journal of neuroscience methods · 2020Review
- An assay of drug-induced emesis in the squirrel monkey (Saimiri sciureus).Journal of medical primatology · 2019Article
- Selective inhibition of small-diameter axons using infrared light.Scientific reports · 2017Article
- Role of the abdominal vagus and hindbrain in inhalational anesthesia-induced vomiting.Autonomic neuroscience : basic & clinical · 2017Article
- Impact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew.Neurogastroenterology and motility · 2016Article
- Hindbrain GLP-1 receptor mediation of cisplatin-induced anorexia and nausea.Physiology & behavior · 2016Article
- Measuring the nausea-to-emesis continuum in non-human animals: refocusing on gastrointestinal vagal signaling.Experimental brain research · 2014Review
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7 authors at 2 institutions in 1 country.
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Abstract
Signals from the vestibular system, area postrema, and forebrain elicit nausea and vomiting, but gastrointestinal (GI) vagal afferent input arguably plays the most prominent role in defense against food poisoning. It is difficult to determine the contribution of GI vagal afferent input on emesis because various agents (e.g., chemotherapy) often act on multiple sensory pathways. Intragastric copper sulfate (CuSO4) potentially provides a specific vagal emetic stimulus, but its actions are not well defined in musk shrews (Suncus murinus), a primary small animal model used to study emesis. The aims of the current study were 1) to investigate the effects of subdiaphragmatic vagotomy on CuSO4-induced emesis and 2) to conduct preliminary transneuronal tracing of the GI-brain pathways in musk shrews. Vagotomy failed to inhibit the number of emetic episodes produced by optimal emetic doses of CuSO4 (60 and 120 mg/kg ig), but the effects of lower doses were dependent on an intact vagus (20 and 40 mg/kg). Vagotomy also failed to affect emesis produced by motion (1 Hz, 10 min) or nicotine administration (5 mg/kg sc). Anterograde transport of the H129 strain of herpes simplex virus-1 from the ventral stomach wall identified the following brain regions as receiving inputs from vagal afferents: the nucleus of the solitary tract, area postrema, and lateral parabrachial nucleus. These data indicate that the contribution of vagal pathways to intragastric CuSO4-induced emesis is dose dependent in musk shrews. Furthermore, the current neural tracing data suggest brain stem anatomical circuits that are activated by GI signaling in the musk shrew.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.