Observational studyJournal of human hypertension2014
Uric acid levels predict future blood pressure and new onset hypertension in the general Japanese population.
Observational study in Journal of human hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association between hyperuricemia and hypertension and the mediatory role of obesity: a large cohort study in China.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Effect of chronic kidney disease on the association between hyperuricemia and new-onset hypertension in the general Japanese population: ISSA-CKD study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study.Frontiers in medicine · 2020Article
- Impact of uric acid on incident hypertension: Sex-specific analysis in different age groups.International Journal of Cardiology. Hypertension · 2019Article
- Relationship between serum uric acid and blood pressure by adjusting dietary factors.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study.PloS one · 2015Article
- Serum uric acid and new-onset hypertension: a possible therapeutic avenue?Journal of human hypertension · 2014Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We tested the hypothesis that uric acid levels predict new-onset hypertension in the Japanese general population. Normotensive individuals who visited our hospital for a yearly health checkup (n=8157, men=61.0% and age=50.7±12.2 years) were enrolled in the present study. After baseline evaluation, participants were followed up for a median of 48.3 months (range 4.9-101.0 months), with the endpoint being the development of hypertension, defined as systolic blood pressure (BP) > or = 140 mm Hg, diastolic BP > or = 90 mm Hg or the use of antihypertensive medication. The impact of uric acid and other cardiovascular risk factors at baseline on future BP and development of hypertension was assessed. During follow-up, 19.0% of women (n=605) and 29.5% of men (n=1469) participants developed hypertension. Incident hypertension was increased across the quartiles for baseline uric acid levels (P<0.0001), and multivariate Cox proportional hazards analysis revealed a significant and independent association between the uric acid level and the onset of hypertension in both men and women participants (P<0.05). Furthermore, uric acid was independently and positively correlated with future BP (P<0.05). Thus, uric acid is an independent predictor of new-onset hypertension in both women and men.
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