ArticleEnvironmental science and pollution research international2014
Cytogenetic biomonitoring of oral mucosa cells of crack cocaine users.
Article in Environmental science and pollution research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Is drug use associated with the presence of periodontitis and oral lesions? A meta-analysis.Journal of periodontal & implant science · 2024Article
- Amelioration of Cytogenotoxic Damage in Drug Abusers Supplemented with Folic Acid.Biomedicines · 2024Article
- Cocaine use and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.Cancer medicine · 2024Article
- Are Cytomorphogenetic Events Correlated with Oral Mucosal Lesions Induced by Crack Cocaine Use? A Systematic Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Review
- Opium, phencyclidine, and crack cocaine smoking associations with lung and upper aerodigestive tract cancers: exploratory findings from a case-control study in Los Angeles County.The American journal of drug and alcohol abuse · 2023Article
- Salivary protein candidates for biomarkers of oral disorders in people with a crack cocaine use disorder.Journal of applied oral science : revista FOB · 2023Article
- Genotoxicity, oxidative stress, and inflammatory response induced by crack-cocaine: relevance to carcinogenesis.Environmental science and pollution research international · 2021Review
- Oral HPV among people who use crack-cocaine: prevalence, genotypes, risk factors, and key interventions in a remote Northern Brazilian region.Clinical oral investigations · 2021Article
- Salivary flow rates and buffer capacity and its relationship with oral health status: a cross-sectional study on crack-cocaine-addicted males.Environmental science and pollution research international · 2020Article
- Argyrophilic nucleolar organizer regions in oral mucosa cells of crack and cocaine users: a cross-sectional study.Environmental science and pollution research international · 2020Article
- Association between oral mucosal lesions and crack and cocaine addiction in men: a cross-sectional study.Environmental science and pollution research international · 2018Article
- Dental health status in crack/cocaine-addicted men: a cross-sectional study.Environmental science and pollution research international · 2017Article
- Periodontal status in crack and cocaine addicted men: a cross-sectional study.Environmental science and pollution research international · 2017Article
- Acute crack cocaine exposure induces genetic damage in multiple organs of rats.Environmental science and pollution research international · 2016Article
- Genomic instability in human lymphocytes from male users of crack cocaine.International journal of environmental research and public health · 2014Article
- Inhibition of Toll Like Signaling Pathway Is Associated With Genomic Instability in Rat Liver Exposed to Crack Cocaine.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to comparatively evaluate genomic damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated oral mucosa cells from crack cocaine users by micronucleus test. A total of 30 crack cocaine users and 30 health controls (non-exposed individuals) were included in this setting. Individuals had epithelial cells from cheek mechanically exfoliated, placed in fixative, and dropped in clean slides, which were checked for the above nuclear phenotypes. The results pointed out significant statistical differences (p < 0.05) of micronucleated oral mucosa cells from crack cocaine users. Exposure to crack cocaine caused an increase of other nuclear alterations closely related to cytotoxicity such as karyolysis in oral cells as well. In summary, these data indicate that crack cocaine is able to induce chromosomal breakage and cellular death in oral mucosa cells of users.
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