ArticleThe ISME journal2014
The role of quorum sensing signalling in EPS production and the assembly of a sludge community into aerobic granules.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Immobilization of Heavy Metals by Microbial Extracellular Polymeric Substances: Key Mechanisms, Driving Factors, and Research Advances.Applied biochemistry and biotechnology · 2026Review
- A novel strategy for a stable low-ammonia nitrification system: low-temperature sludge storage recovery.RSC advances · 2026Article
- Quorum sensing for carbon-neutral wastewater treatment: Mechanisms, challenges, technological pathways, and future prospects.Environmental science and ecotechnology · 2026Review
- Endogenous quorum sensing orchestrates microbial social behaviors for anaerobic digestion adaptation to temperature reduction.Environmental microbiome · 2026Article
- Article
- Exploring the Role of Berberine as a Molecular Disruptor in Antimicrobial Strategies.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Multiple extracellular polymeric substance pathways transcribed byApplied and environmental microbiology · 2025Article
- Microbial extracellular polymeric substances in the environment, technology and medicine.Nature reviews. Microbiology · 2025Review
- Exploring interspecific interaction variability in microbiota: A review.Engineering microbiology · 2024Review
- Methanogenic partner influences cell aggregation and signalling of Syntrophobacterium fumaroxidans.Applied microbiology and biotechnology · 2024Article
- A new strategy for greenhouse gas emission reduction in the anaerobic/anoxic/oxic biological treatment process using exogenous N-acyl-homoserine lactones, a quorum-sensing signaling molecules.Water science and technology : a journal of the International Association on Water Pollution Research · 2024Article
- Article
- Plant-microbe interactions through a lens: tales from the mycorrhizosphere.Annals of botany · 2024Review
- Regulation of quorum sensing activities by the stringent response geneFrontiers in microbiology · 2024Article
- Unifying concepts in methanogenic, aerobic, and anammox sludge granulation.Environmental science and ecotechnology · 2024Review
- Review
- Challenges of aerobic granular sludge utilization: Fast start-up strategies and cationic pollutant removal.Heliyon · 2023Review
- Evidence for Complex Interplay between Quorum Sensing and Antibiotic Resistance in Pseudomonas aeruginosa.Microbiology spectrum · 2022Article
- Quorum Sensing and Quorum Quenching with a Focus on Cariogenic and Periodontopathic Oral Biofilms.Microorganisms · 2022Review
- Exploring the Function of Quorum Sensing Regulated Biofilms in Biological Wastewater Treatment: A Review.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing (QS) signalling has been extensively studied in single species populations. However, the ecological role of QS in complex, multi-species communities, particularly in the context of community assembly, has neither been experimentally explored nor theoretically addressed. Here, we performed a long-term bioreactor ecology study to address the links between QS, organization and composition of complex microbial communities. The conversion of floccular biomass to highly structured granules was found to be non-random, but strongly and positively correlated with N-acyl-homoserine-lactone (AHL)-mediated QS. Specific AHLs were elevated up to 100-fold and were strongly associated with the initiation of granulation. Similarly, the levels of particular AHLs decreased markedly during the granular disintegration phase. Metadata analysis indicated that granulation was accompanied by changes in extracellular polymeric substance (EPS) production and AHL add-back studies also resulted in increased EPS synthesis. In contrast to the commonly reported nanomolar to micromolar signal concentrations in pure culture laboratory systems, QS signalling in the granulation ecosystem occurred at picomolar to nanomolar concentrations of AHLs. Given that low concentrations of AHLs quantified in this study were sufficient to activate AHL bioreporters in situ in complex granular communities, AHL mediated QS may be a common feature in many natural and engineered ecosystems, where it coordinates community behaviour.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.