ArticleMolecular imaging and biology2014
Accurate PET/MR quantification using time of flight MLAA image reconstruction.
Article in Molecular imaging and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Impact of improved attenuation correction on 18F-FDG PET/MR hybrid imaging of the heart.PloS one · 2019Trial
- Improvements in PET Image Quality in Time of Flight (TOF) Simultaneous PET/MRI.Molecular imaging and biology · 2016Trial
- Zero-TE MRI-based attenuation correction for bone components on chest [Annals of nuclear medicine · 2026Article
- Feasibility of PET-enabled dual-energy CT imaging: First physical phantom and initial patient study results.European journal of nuclear medicine and molecular imaging · 2025Article
- Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024Review
- International EANM-SNMMI-ISMRM consensus recommendation for PET/MRI in oncology.European journal of nuclear medicine and molecular imaging · 2023Article
- A review of PET attenuation correction methods for PET-MR.EJNMMI physics · 2023Review
- A quantitative clinical evaluation of simultaneous reconstruction of attenuation and activity in time-of-flight PET.BMC medical imaging · 2023Article
- Quantitative evaluation of a deep learning-based framework to generate whole-body attenuation maps using LSO background radiation in long axial FOV PET scanners.European journal of nuclear medicine and molecular imaging · 2022Article
- Deep learning-based T1-enhanced selection of linear attenuation coefficients (DL-TESLA) for PET/MR attenuation correction in dementia neuroimaging.Magnetic resonance in medicine · 2021Article
- New Data-Driven Gated PET/CT Free of Misregistration Artifacts.International journal of radiation oncology, biology, physics · 2021Article
- Attenuation correction for human PET/MRI studies.Physics in medicine and biology · 2020Article
- Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers.European journal of nuclear medicine and molecular imaging · 2020Article
- Generation of PET Attenuation Map for Whole-Body Time-of-FlightJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- No significant difference found in PET/MRI CBF values reconstructed with CT-atlas-based and ZTE MR attenuation correction.EJNMMI research · 2019Article
- Zero-Extra-Dose PET Delayed Imaging with Data-Driven Attenuation Correction Estimation.Molecular imaging and biology · 2019Article
- Evaluation of zero-echo-time attenuation correction for integrated PET/MR brain imaging-comparison to head atlas andEJNMMI physics · 2018Article
- Joint Reconstruction of Activity and Attenuation in Time-of-Flight PET: A Quantitative Analysis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- SMART (SiMulAtion and ReconsTruction) PET: an efficient PET simulation-reconstruction tool.EJNMMI physics · 2018Article
- Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneousEJNMMI research · 2018Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeQuantification of positron emission tomography/magnetic resonance imaging (PET/MRI) studies is hampered by inaccurate MR-based attenuation correction (MR-AC). To date, most studies on MR-AC have been performed using PET/MR systems without time of flight (TOF). Maximum likelihood reconstruction of attenuation and activity (MLAA), however, has the potential to improve MR-AC by exploiting TOF. The purpose of this study is to assess the impact of MR-AC on PET image quantification for TOF-PET/MR systems and to evaluate PET accuracy when using TOF in combination with MLAA (TOF-MLAA). PROCEDURES: Simulations were designed to evaluate (1) the impact of MR-AC on PET quantification for different TOF windows (667, 500, 333 and 167 ps) and (2) use of TOF-MLAA for improving PET quantification. TOF-ordered subset expectation maximisation (OSEM) and TOF-MLAA reconstructions using MR-AC were compared with those obtained using TOF-OSEM with computed tomography-based AC (CT-AC).
resultsOSEM reconstructions without TOF showed a negative MR-AC-induced bias of -50 % in the bone. TOF-OSEM was able to reduce this bias down to -15 %, with more accurate results for better TOF. TOF-MLAA was able to reduce the bias to within 5 % but at the cost of a ∼40 % increase in image variance.
conclusionsTOF-MLAA can improve quantitative PET accuracy of PET/MR studies. Further improvements are anticipated with improving TOF performance.
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