ArticleJournal of the Royal Society, Interface2014
How sticky should a virus be? The impact of virus binding and release on transmission fitness using influenza as an example.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Swine H1N1 Influenza Virus Variants with Enhanced Polymerase Activity and HA Stability Promote Airborne Transmission in Ferrets.Journal of virology · 2022Article
- Virions and respiratory droplets in air: Diffusion, drift, and contact with the epithelium.Bio Systems · 2020Review
- Interaction of the Amino-Terminal Domain of the ISAV Fusion Protein with a Cognate Cell Receptor.Pathogens (Basel, Switzerland) · 2020Article
- Interaction of a Densovirus with Glycans of the Peritrophic Matrix Mediates Oral Infection of the Lepidopteran PestViruses · 2019Article
- Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread.Nature communications · 2019Article
- Towards a thermodynamic mechanistic model for the effect of temperature on arthropod vector competence for transmission of arboviruses.Microbial risk analysis · 2019Article
- Using thermodynamic parameters to calibrate a mechanistic dose-response for infection of a host by a virus.Microbial risk analysis · 2018Article
- A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach.The Journal of infectious diseases · 2017Article
- Host heterogeneity affects both parasite transmission to and fitness on subsequent hosts.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
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- Within-Host Models of High and Low Pathogenic Influenza Virus Infections: The Role of Macrophages.PloS one · 2016Article
- Crossing the scale from within-host infection dynamics to between-host transmission fitness: a discussion of current assumptions and knowledge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Diffusion-limited attachment of large spherical particles to flexible membrane-immobilized receptors.European biophysics journal : EBJ · 2015Article
- Assessing Uncertainty in A2 Respiratory Syncytial Virus Viral Dynamics.Computational and mathematical methods in medicine · 2015Article
- Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus.Trends in microbiology · 2014Review
- Trade-offs between and within scales: environmental persistence and within-host fitness of avian influenza viruses.Proceedings. Biological sciences · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Budding viruses face a trade-off: virions need to efficiently attach to and enter uninfected cells while newly generated virions need to efficiently detach from infected cells. The right balance between attachment and detachment-the right amount of stickiness-is needed for maximum fitness. Here, we design and analyse a mathematical model to study in detail the impact of attachment and detachment rates on virus fitness. We apply our model to influenza, where stickiness is determined by a balance of the haemagglutinin (HA) and neuraminidase (NA) proteins. We investigate how drugs, the adaptive immune response and vaccines impact influenza stickiness and fitness. Our model suggests that the location in the 'stickiness landscape' of the virus determines how well interventions such as drugs or vaccines are expected to work. We discuss why hypothetical NA enhancer drugs might occasionally perform better than the currently available NA inhibitors in reducing virus fitness. We show that an increased antibody or T-cell-mediated immune response leads to maximum fitness at higher stickiness. We further show that antibody-based vaccines targeting mainly HA or NA, which leads to a shift in stickiness, might reduce virus fitness above what can be achieved by the direct immunological action of the vaccine. Overall, our findings provide potentially useful conceptual insights for future vaccine and drug development and can be applied to other budding viruses beyond influenza.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.