ArticleJournal of the Royal Society, Interface2014
Synergy of cell-cell repulsion and vacuolation in a computational model of lumen formation.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- A 3D multi-agent-based model for lumen morphogenesis: the role of the biophysical properties of the extracellular matrix.Engineering with computers · 2022Article
- Biologically-Based Mathematical Modeling of Tumor Vasculature and Angiogenesis via Time-Resolved Imaging Data.Cancers · 2021Review
- Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model.PLoS computational biology · 2020Article
- Article
- Adapting a Plant Tissue Model to Animal Development: Introducing Cell Sliding into VirtualLeaf.Bulletin of mathematical biology · 2019Article
- Angiogenic Factors produced by Hypoxic Cells are a leading driver of Anastomoses in Sprouting Angiogenesis-a computational study.Scientific reports · 2018Article
- A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis.Frontiers in physiology · 2017Article
- A new paradigm for animal symmetry.Interface focus · 2015Review
- Fabrication of Biomimetic Bone Tissue Using Mesenchymal Stem Cell-Derived Three-Dimensional Constructs Incorporating Endothelial Cells.PloS one · 2015Article
- "You Shall Not Pass"-tight junctions of the blood brain barrier.Frontiers in neuroscience · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key step in blood vessel development (angiogenesis) is lumen formation: the hollowing of vessels for blood perfusion. Two alternative lumen formation mechanisms are suggested to function in different types of blood vessels. The vacuolation mechanism is suggested for lumen formation in small vessels by coalescence of intracellular vacuoles, a view that was extended to extracellular lumen formation by exocytosis of vacuoles. The cell-cell repulsion mechanism is suggested to initiate extracellular lumen formation in large vessels by active repulsion of adjacent cells, and active cell shape changes extend the lumen. We used an agent-based computer model, based on the cellular Potts model, to compare and study both mechanisms separately and combined. An extensive sensitivity analysis shows that each of the mechanisms on its own can produce lumens in a narrow region of parameter space. However, combining both mechanisms makes lumen formation much more robust to the values of the parameters, suggesting that the mechanisms may work synergistically and operate in parallel, rather than in different vessel types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.